Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.34 |
| ▸ | NPY4R | P50391 | 7/20 | 0.33 |
| ▸ | NPY1R | P25929 | 5/20 | 0.33 |
| ▸ | NPY2R | P49146 | 4/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.33 |
| ▸ | OTC | P00480 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 2/20 | 0.31 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.31 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.31 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL29157307 | 1.00 | PRCP (0.35) | PRCPSLC7A5NPY4RNPY1RNPY2R | |
| Arginine SCHEMBL6027855 | 0.96 | PRCP (0.33) | PRCPSLC7A5NPY4RNPY1RNPY2R | |
| Arginine SCHEMBL21437185 | 0.96 | PRCP (0.33) | PRCPSLC7A5NPY4RNPY1RNPY2R | |
| Arginine SCHEMBL16279880 | 0.96 | PRCP (0.33) | PRCPSLC7A5NPY4RNPY1RNPY2R | |
| Arginine SCHEMBL28883128 | 0.96 | PRCP (0.33) | PRCPSLC7A5NPY4RNPY1RNPY2R | |
| Arginine SCHEMBL28033048 | 0.96 | PRCP (0.33) | PRCPSLC7A5NPY4RNPY1RNPY2R | |
| Arginine SCHEMBL1697257 | 0.95 | PRCP (0.38) | PRCPSLC7A5NPY4RNPY1RNPY2R | |
| Arginine SCHEMBL28419523 | 0.95 | PRCP (0.38) | PRCPSLC7A5NPY4RNPY1RNPY2R | |
| Arginine SCHEMBL3195919 | 0.94 | GSR (0.33) | PRCPSLC7A5NPY4RNPY1RNPY2R | |
| Arginine SCHEMBL2459501 | 0.93 | PRCP (0.37) | PRCPSLC7A5NPY4RNPY1RNPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090123972-A1 | Staphylococcal nuclease fusion proteins for the production of recombinant peptides | NATIONAL RESEARCH COUNCIL OF CANADA | 2009-05-14 | — | — | US | disclosed |
| US-7390639-B2 | Staphylococcal nuclease fusion proteins for the production of recombinant peptides | NATIONAL RESEARCH COUNCIL OF CANADA | 2008-06-24 | — | — | US | disclosed |
| US-20060173164-A1 | Staphylococcal nuclease fusion proteins for the produciton of recombinant peptides | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2006-08-03 | — | — | US | disclosed |
| EP-1527181-A1 | STAPHYLOCOCCAL NUCLEASE FUSION PROTEINS FOR THE PRODUCTION OF RECOMBINANT PEPTIDES | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004015111-A1 | STAPHYLOCOCCAL NUCLEASE FUSION PROTEINS FOR THE PRODUCTION OF RECOMBINANT PEPTIDES | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2004-02-19 | — | — | WO | disclosed |