Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 4/20 | 0.38 |
| ▸ | IGF1R | P08069 | 3/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | JAK1 | P23458 | 4/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28887519 | 0.91 | JAK3 (0.46) | HTTJAK3IGF1RPTK2ABL1 | |
| SCHEMBL28887549 | 0.89 | HTT (0.41) | HTTJAK3IGF1RPTGDR2TAS2R8 | |
| SCHEMBL28959064 | 0.88 | JAK1 (0.44) | HTTJAK3PTGDR2TAS2R8JAK2 | |
| SCHEMBL28887565 | 0.88 | JAK3 (0.51) | JAK3IGF1RPTK2JAK2JAK1 | |
| SCHEMBL28887536 | 0.87 | JAK2 (0.41) | HTTJAK3PTGDR2JAK2JAK1 | |
| SCHEMBL28887538 | 0.87 | JAK3 (0.42) | JAK3IGF1RPTK2CYP11B2JAK2 | |
| SCHEMBL29523014 | 0.87 | IGF1R (0.40) | JAK3IGF1RPTK2CYP11B2JAK2 | |
| SCHEMBL28887527 | 0.86 | JAK3 (0.45) | HTTJAK3JAK2JAK1TYK2 | |
| SCHEMBL28887561 | 0.81 | EGFR (0.41) | JAK3IGF1RJAK2JAK1KDR | |
| SCHEMBL28887570 | 0.79 | JAK3 (0.45) | JAK3JAK2JAK1TYK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114292274-B | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2023-12-19 | — | — | CN | claimed |
| CN-114292274-A | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2022-04-08 | — | — | CN | claimed |
| CN-114292274-B | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2023-12-19 | — | — | CN | disclosed |
| CN-114292274-A | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2022-04-08 | — | — | CN | disclosed |