Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28384221 | 0.97 | HPGD (0.51) | HPGDALDH1A1MAPK10TSHRPOLB | |
| SCHEMBL29033220 | 0.96 | HPGD (0.52) | HPGDALDH1A1MAPK10TSHRPOLB | |
| SCHEMBL20598375 | 0.83 | SMN1; SMN2 (0.56) | HPGDALDH1A1MAPK10TSHRCSF1R | |
| SCHEMBL28380657 | 0.81 | IRAK4 (0.64) | ALDH1A1TSHRPOLBSMN1; SMN2KDM4E | |
| SCHEMBL20598851 | 0.81 | CSF1R (0.54) | HPGDCSF1RSMN1; SMN2GAAMAPT | |
| SCHEMBL20598310 | 0.80 | CSF1R (0.55) | HPGDTSHRCSF1RSMN1; SMN2GAA | |
| SCHEMBL20598344 | 0.80 | CSF1R (0.55) | HPGDCSF1RSMN1; SMN2GAAMAPT | |
| SCHEMBL20598458 | 0.79 | IRAK4 (0.50) | HPGDALDH1A1MAPK10TSHRPOLB | |
| SCHEMBL28383182 | 0.79 | IRAK4 (0.68) | ALDH1A1TSHRPOLBSMN1; SMN2KDM4E | |
| SCHEMBL28383358 | 0.79 | CHEK1 (0.69) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032642-A | Kinase inhibitors and methods of making and using | 里格尔药品股份有限公司 | 2020-04-17 | — | — | CN | claimed |
| CN-111032642-A | Kinase inhibitors and methods of making and using | 里格尔药品股份有限公司 | 2020-04-17 | — | — | CN | disclosed |