Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Tinidazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.92 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.92 |
| ▸ | CA1 | P00915 | 7/20 | 0.69 |
| ▸ | CA2 | P00918 | 7/20 | 0.69 |
| ▸ | CA9 | Q16790 | 7/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | THRB | P10828 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | CA12 | O43570 | 6/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 4/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tinidazole SCHEMBL27865473 | 0.96 | LMNA (0.94) | LMNASMN1; SMN2CA1CA2CA9 | |
| Tinidazole SCHEMBL21141 | 0.96 | LMNA (1.00) | LMNASMN1; SMN2CA1CA2CA9 | |
| Tinidazole SCHEMBL14742527 | 0.96 | LMNA (1.00) | LMNASMN1; SMN2CA1CA2CA9 | |
| Tinidazole SCHEMBL19149564 | 0.95 | LMNA (0.87) | LMNASMN1; SMN2CA1CA2CA9 | |
| Tinidazole SCHEMBL27877209 | 0.94 | LMNA (0.97) | LMNASMN1; SMN2CA1CA2CA9 | |
| Tinidazole SCHEMBL27640947 | 0.94 | LMNA (0.97) | LMNASMN1; SMN2CA1CA2CA9 | |
| SCHEMBL11579155 | 0.90 | LMNA (0.89) | LMNASMN1; SMN2CA1CA2CA9 | |
| SCHEMBL11521582 | 0.86 | LMNA (0.82) | LMNASMN1; SMN2CA1CA2CA9 | |
| Tinidazole SCHEMBL20840295 | 0.85 | LMNA (0.74) | LMNASMN1; SMN2CA1CA2CA9 | |
| Tinidazole SCHEMBL20770937 | 0.85 | LMNA (0.74) | LMNASMN1; SMN2CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111000800-A | Temperature-sensitive micelle vaginal spray and preparation method thereof | 江苏中天药业有限公司 | 2020-04-14 | — | — | CN | disclosed |