Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 1.00 |
| ▸ | RAB9A | P51151 | 5/20 | 1.00 |
| ▸ | NPC1 | O15118 | 4/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | ALPL | P05186 | 7/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.75 |
| ▸ | CA9 | Q16790 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | ACR | P10323 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1414008 | 0.86 | MAPT (1.00) | MAPTRAB9ANPC1L3MBTL1ALPL | |
| SCHEMBL4714286 | 0.86 | MAPT (0.77) | MAPTRAB9ANPC1L3MBTL1ALPL | |
| SCHEMBL19533601 | 0.86 | MAPT (0.75) | MAPTRAB9ANPC1L3MBTL1ALPL | |
| SCHEMBL4683636 | 0.86 | MAPT (0.75) | MAPTRAB9ANPC1L3MBTL1ALPL | |
| SCHEMBL25168483 | 0.85 | ALPL (0.76) | MAPTRAB9ANPC1L3MBTL1ALPL | |
| SCHEMBL1413959 | 0.85 | ALPL (1.00) | MAPTRAB9ANPC1L3MBTL1ALPL | |
| SCHEMBL2824803 | 0.85 | ALPL (0.76) | MAPTRAB9ANPC1L3MBTL1ALPL | |
| SCHEMBL19544602 | 0.85 | MAPT (0.73) | MAPTRAB9ANPC1L3MBTL1ALPL | |
| SCHEMBL595997 | 0.85 | ALPL (0.75) | MAPTRAB9ANPC1L3MBTL1ALPL | |
| SCHEMBL4712555 | 0.83 | ALPL (0.73) | MAPTRAB9ANPC1L3MBTL1ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104814956-A | Use of ethyl (S)-1-(3-p-chlorophenoxy-2-hydroxypropyl)-3-p-methoxyphenyl-1H-pyrazolyl-5-carboxylate in pharmacy | UNIV SHANDONG | 2015-08-05 | — | — | CN | disclosed |
| US-7645756-B2 | 6-[4-(3-piperidin-1-ylpropoxy)-phenyl]-[1,2,4]triazolo[4,3-b]pyridazine; has histamine-H3 receptor antagonistic effect or a histamine-H3 receptor inverse-agonistic effect; for metabolic system, circulatory system or nervous system diseases | BANYU PHARMACEUTICAL CO. LTD. (JP) | 2010-01-12 | — | — | US | disclosed |
| US-20070167453-A1 | Nitrogenous fused heteroaromatic ring derivative | MSD K.K. (JP) | 2007-07-19 | — | — | US | disclosed |
| EP-1719756-A1 | NITROGENOUS FUSED HETEROAROMATIC RING DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-11-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167453-A1 | Nitrogenous fused heteroaromatic ring derivative | HRH3, HRH2, HRH4 | MAPT 3450/4885RAB9A 3692/4885NPC1 2186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.