Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetone SCHEMBL27271046 | 0.89 | GAA (0.52) | ALDH1A1GAAHSD17B10TDP1CA1 | |
| SCHEMBL31231738 | 0.89 | GAA (0.62) | ALDH1A1GAAHSD17B10TDP1CA1 | |
| SCHEMBL1586 | 0.89 | GAA (0.62) | ALDH1A1GAAHSD17B10TDP1CA1 | |
| Bicarbonate SCHEMBL28890667 | 0.87 | GAA (0.50) | ALDH1A1GAAHSD17B10TDP1CA1 | |
| Benzene SCHEMBL28843734 | 0.86 | ALDH1A1 (0.61) | ALDH1A1GAAHSD17B10TDP1CA1 | |
| SCHEMBL31058081 | 0.86 | GAA (0.59) | ALDH1A1GAAHSD17B10TDP1CA1 | |
| SCHEMBL6621808 | 0.86 | GAA (0.59) | ALDH1A1GAAHSD17B10TDP1CA1 | |
| Water SCHEMBL6162445 | 0.86 | GAA (0.59) | ALDH1A1GAAHSD17B10TDP1CA1 | |
| Hydrochloric Acid SCHEMBL29967262 | 0.86 | GAA (0.59) | ALDH1A1GAAHSD17B10TDP1CA1 | |
| Hydrochloric Acid SCHEMBL2833772 | 0.86 | GAA (0.59) | ALDH1A1GAAHSD17B10TDP1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111100128-B | Synthetic method of Ribocini intermediate product and intermediate compound thereof | 广安凯特制药有限公司 | 2022-09-06 | — | — | CN | claimed |
| CN-111100128-A | Synthetic method of Ribocini intermediate product and intermediate compound thereof | 广安凯特制药有限公司 | 2020-05-05 | — | — | CN | claimed |
| CN-111100128-B | Synthetic method of Ribocini intermediate product and intermediate compound thereof | 广安凯特制药有限公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-111100128-A | Synthetic method of Ribocini intermediate product and intermediate compound thereof | 广安凯特制药有限公司 | 2020-05-05 | — | — | CN | disclosed |