Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | PDE5A | O76074 | 17/20 | 0.70 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.69 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | ABCC5 | O15440 | 2/20 | 0.67 |
| ▸ | PDE2A | O00408 | 2/20 | 0.67 |
| ▸ | PDE9A | O76083 | 2/20 | 0.67 |
| ▸ | PDE4A | P27815 | 2/20 | 0.67 |
| ▸ | PDE6C | P51160 | 2/20 | 0.67 |
| ▸ | PDE1A | P54750 | 2/20 | 0.67 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.67 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.66 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.65 |
| ▸ | PDE6D | O43924 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29602236 | 0.91 | KDM4E (0.68) | KDM4EPDE5AHDAC3HDAC1HDAC2 | |
| SCHEMBL23361343 | 0.91 | PDE5A (0.74) | KDM4EPDE5AHDAC3HDAC1HDAC2 | |
| SCHEMBL29602240 | 0.91 | PDE5A (0.74) | KDM4EPDE5AHDAC3HDAC1HDAC2 | |
| SCHEMBL29601635 | 0.89 | PDE5A (0.76) | KDM4EPDE5AHDAC3HDAC1HDAC2 | |
| SCHEMBL23361310 | 0.89 | PDE5A (0.76) | KDM4EPDE5AHDAC3HDAC1HDAC2 | |
| SCHEMBL23362150 | 0.89 | KDM4E (0.78) | KDM4EPDE5AHDAC3HDAC1HDAC2 | |
| SCHEMBL29601997 | 0.89 | KDM4E (0.78) | KDM4EPDE5AHDAC3HDAC1HDAC2 | |
| SCHEMBL23370692 | 0.89 | PDE5A (0.77) | KDM4EPDE5AHDAC3HDAC1HDAC2 | |
| SCHEMBL23370716 | 0.86 | KDM4E (0.69) | KDM4EPDE5AHDAC3HDAC1HDAC2 | |
| SCHEMBL23370767 | 0.85 | KDM4E (0.67) | KDM4EPDE5AHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115038704-A | Nitrogen oxide donating PDE-5 and/or PDE-6 inhibitor compounds | 日东制药股份有限公司 | 2022-09-09 | — | — | CN | disclosed |