Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.76 |
| ▸ | PDE2A | O00408 | 2/20 | 0.74 |
| ▸ | PDE9A | O76083 | 2/20 | 0.74 |
| ▸ | PDE4A | P27815 | 2/20 | 0.74 |
| ▸ | PDE6C | P51160 | 2/20 | 0.74 |
| ▸ | PDE1A | P54750 | 2/20 | 0.74 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.74 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.68 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.67 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.67 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.64 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23361310 | 1.00 | PDE5A (0.76) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL23370692 | 0.98 | PDE5A (0.77) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL23361343 | 0.96 | PDE5A (0.74) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL29602240 | 0.96 | PDE5A (0.74) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL23361697 | 0.90 | PDE5A (0.65) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL23370767 | 0.90 | KDM4E (0.67) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL28890828 | 0.89 | KDM4E (0.73) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL29601997 | 0.88 | KDM4E (0.78) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL23362150 | 0.88 | KDM4E (0.78) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL23370716 | 0.88 | KDM4E (0.69) | PDE5APDE2APDE9APDE4APDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4058457-A2 | NITROGEN OXIDE-DONATING PDE-5 AND/OR PDE-6 INHIBITOR COMPOUNDS | Ildong Pharmaceutical Co., Ltd. (KR) | 2022-09-21 | — | — | EP | disclosed |
| US-20220153746-A1 | NITROGEN OXIDE-DONATING PDE-5 AND/OR PDE-6 INHIBITOR COMPOUNDS, AND USES THEREOF | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2022-05-19 | — | — | US | disclosed |
| WO-2022096930-A2 | NITROGEN OXIDE-DONATING PDE-5 AND/OR PDE-6 INHIBITOR COMPOUNDS, AND USES THEREOF | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2022-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153746-A1 | NITROGEN OXIDE-DONATING PDE-5 AND/OR PDE-6 INHIBITOR COMPOUNDS, AND USES THEREOF | PDE6G, PRKG1, PDE6D | PDE5A 4/4885PDE2A 8/4885PDE9A 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.