Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | BRD1 | O95696 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26739624 | 0.81 | — | — | |
| SCHEMBL12035985 | 0.76 | MAPT (0.41) | MAPTALDH1A1KDM4EHIF1AEPAS1 | |
| SCHEMBL8104414 | 0.76 | MAPT (0.41) | MAPTALDH1A1KDM4EHIF1AEPAS1 | |
| SCHEMBL14930304 | 0.75 | HTR2A (0.45) | MAPTHIF1AEPAS1HTR2AGAA | |
| SCHEMBL5546004 | 0.74 | MAPT (0.44) | MAPTALDH1A1KDM4EHIF1AEPAS1 | |
| SCHEMBL15724661 | 0.74 | AKR1B1 (0.46) | MAPTALDH1A1KDM4EHIF1AEPAS1 | |
| SCHEMBL10573500 | 0.74 | HTR2A (0.40) | MAPTPKMALDH1A1KDM4EHIF1A | |
| SCHEMBL5546007 | 0.74 | MAPT (0.60) | MAPTALDH1A1KDM4ETDP1LMNA | |
| SCHEMBL3047236 | 0.74 | AKT1 (0.44) | MAPTALDH1A1KDM4EHIF1AEPAS1 | |
| SCHEMBL5269029 | 0.74 | MAPT (0.40) | MAPTALDH1A1KDM4EHIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117466803-A | Compounds, salts thereof and methods for treating diseases | 阿卡蒂亚药品公司 | 2024-01-30 | — | — | CN | disclosed |
| CN-111132976-B | Compounds, salts thereof and methods for treating diseases | 阿卡蒂亚药品公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-111132976-A | Compounds, salts thereof and methods for treating diseases | 阿卡蒂亚药品公司 | 2020-05-08 | — | — | CN | disclosed |