Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.53 |
| ▸ | EIF4A1 | P60842 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28891174 | 0.92 | DHODH (0.56) | DHODHEIF4A1KDM4ELMNATP53 | |
| SCHEMBL28891175 | 0.90 | DHODH (0.55) | DHODHEIF4A1KDM4ELMNATP53 | |
| SCHEMBL28891171 | 0.90 | DHODH (0.58) | DHODHEIF4A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL28885855 | 0.87 | DHODH (0.65) | DHODHEIF4A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL28891179 | 0.85 | DHODH (0.55) | DHODHEIF4A1KDM4ELMNATP53 | |
| SCHEMBL28891198 | 0.85 | DHODH (0.57) | DHODHEIF4A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL28891182 | 0.84 | DHODH (0.53) | DHODHEIF4A1KDM4ELMNATP53 | |
| SCHEMBL23579651 | 0.84 | DHODH (0.63) | DHODHEIF4A1KDM4ELMNATP53 | |
| SCHEMBL29997219 | 0.84 | DHODH (0.63) | DHODHEIF4A1KDM4ELMNATP53 | |
| SCHEMBL23590086 | 0.82 | DHODH (0.59) | DHODHKDM4ELMNATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115361948-A | Methods and compositions for inhibiting dihydroorotate dehydrogenase | 俄亥俄州国家创新基金会 | 2022-11-18 | — | — | CN | disclosed |