Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 8/20 | 0.50 |
| ▸ | ROS1 | P08922 | 8/20 | 0.50 |
| ▸ | FLT3 | P36888 | 8/20 | 0.50 |
| ▸ | EML4 | Q9HC35 | 7/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.50 |
| ▸ | EGFR | P00533 | 7/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | STAT6 | P42226 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29875589 | 0.81 | RET (0.58) | RETROS1FLT3EML4ALK | |
| SCHEMBL28891673 | 0.81 | RET (0.58) | RETROS1FLT3EML4ALK | |
| SCHEMBL25561902 | 0.72 | RET (0.59) | RETROS1FLT3EML4ALK | |
| SCHEMBL10127376 | 0.72 | EML4 (0.67) | RETROS1FLT3EML4ALK | |
| SCHEMBL13405469 | 0.72 | PIM1 (0.52) | RETROS1FLT3EML4ALK | |
| SCHEMBL16195676 | 0.72 | EML4 (0.70) | RETROS1FLT3EML4ALK | |
| SCHEMBL13405471 | 0.71 | MAPT (0.53) | RETROS1FLT3EML4ALK | |
| SCHEMBL282875 | 0.70 | RET (0.55) | RETROS1FLT3EML4ALK | |
| SCHEMBL10128020 | 0.70 | RET (0.69) | RETROS1FLT3EML4ALK | |
| SCHEMBL13405489 | 0.70 | PIM1 (0.64) | RETROS1FLT3EML4ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197154-A | HPK1 inhibitor and application thereof in medicine | 贝达药业股份有限公司 | 2022-10-18 | — | — | CN | disclosed |