Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.75 |
| ▸ | GSK3A | P49840 | 4/20 | 0.73 |
| ▸ | PRKCA | P17252 | 2/20 | 0.68 |
| ▸ | RGS4 | P49798 | 11/20 | 0.62 |
| ▸ | RGS8 | P57771 | 11/20 | 0.62 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.62 |
| ▸ | CDK1 | P06493 | 1/20 | 0.62 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.62 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28959427 | 0.90 | GSK3B (0.69) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL23763548 | 0.86 | GSK3B (0.77) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL2107561 | 0.86 | GSK3B (1.00) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL2107216 | 0.85 | GSK3B (1.00) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL23763497 | 0.84 | GSK3B (0.75) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL23763500 | 0.84 | GSK3B (0.77) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL23763545 | 0.84 | GSK3B (0.75) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL13562490 | 0.82 | RGS4 (0.75) | GSK3BGSK3APRKCARGS4RGS8 | |
| Krm-7777 SCHEMBL3384141 | 0.81 | GSK3B (1.00) | GSK3BGSK3APRKCARGS4RGS8 | |
| SCHEMBL2107221 | 0.77 | RGS4 (1.00) | GSK3BGSK3APRKCARGS4RGS8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116675653-B | Aminoalkyl substituted 1,2, 4-thiadiazolidine-3, 5-dione compound, preparation method and application thereof | 中国药科大学 | 2024-10-01 | — | — | CN | disclosed |
| CN-116675653-A | Aminoalkyl substituted 1,2, 4-thiadiazolidine-3, 5-dione compound, preparation method and application thereof | 中国药科大学 | 2023-09-01 | — | — | CN | disclosed |
| CN-115197167-B | 1,2, 4-thiadiazolidine-3, 5-dione compound, and preparation method and application thereof | 中国药科大学 | 2023-07-28 | — | — | CN | disclosed |
| CN-115197167-A | 1,2,4-thiadiazolidine-3,5-diketone compound and preparation method and application thereof | 中国药科大学 | 2022-10-18 | — | — | CN | disclosed |