Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mk-0941 Free Base. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mk-0941 Free Base SCHEMBL29694365 | 0.98 | GCK (1.00) | GCKKCNH2 | |
| Mk-0941 Free Base SCHEMBL2883693 | 0.98 | GCK (1.00) | GCKKCNH2 | |
| Mk-0941 Free Base SCHEMBL826456 | 0.98 | GCK (1.00) | GCKKCNH2 | |
| SCHEMBL13255221 | 0.93 | GCK (0.89) | GCKKCNH2 | |
| SCHEMBL3599019 | 0.93 | GCK (0.89) | GCKKCNH2 | |
| SCHEMBL13255199 | 0.92 | GCK (0.85) | GCKKCNH2 | |
| SCHEMBL670154 | 0.92 | GCK (0.85) | GCKKCNH2 | |
| SCHEMBL926397 | 0.92 | GCK (0.89) | GCKKCNH2 | |
| SCHEMBL2889405 | 0.92 | GCK (0.85) | GCKKCNH2 | |
| SCHEMBL3594456 | 0.92 | GCK (0.88) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222394-A1 | METHOD FOR PRODUCING PYRAZOL-3-YL-BENZAMIDE DERIVATIVE | MSD K.K. (JP) | 2010-09-02 | — | — | US | claimed |
| US-20100222394-A1 | METHOD FOR PRODUCING PYRAZOL-3-YL-BENZAMIDE DERIVATIVE | MSD K.K. (JP) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222394-A1 | METHOD FOR PRODUCING PYRAZOL-3-YL-BENZAMIDE DERIVATIVE | CBR3, AADAC, KARS1 | GCK 708/4885KCNH2 449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.