Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.47 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | LPL | P06858 | 1/20 | 0.37 |
| ▸ | LIPC | P11150 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28894627 | 1.00 | ABL1 (0.47) | ABL1METAP2RAF1BRAFMAPK1 | |
| SCHEMBL30085487 | 1.00 | ABL1 (0.47) | ABL1METAP2RAF1BRAFMAPK1 | |
| SCHEMBL30085878 | 0.88 | PIK3CA (0.42) | ABL1 | |
| SCHEMBL28894592 | 0.88 | PIK3CA (0.42) | ABL1 | |
| SCHEMBL30085661 | 0.88 | PIK3CA (0.42) | ABL1 | |
| SCHEMBL28894588 | 0.88 | PIK3CA (0.42) | ABL1 | |
| SCHEMBL28894671 | 0.86 | CYP3A4 (0.48) | ABL1IDH2 | |
| SCHEMBL30085381 | 0.86 | CYP3A4 (0.48) | ABL1IDH2 | |
| SCHEMBL28894669 | 0.86 | CYP3A4 (0.48) | ABL1IDH2 | |
| SCHEMBL25460158 | 0.82 | METAP2 (0.39) | ABL1METAP2RAF1BRAFIDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115397818-A | Aminopyrimidine derivatives and their use as modulators of arene receptors | 东亚ST株式会社 | 2022-11-25 | — | — | CN | claimed |
| CN-115397818-A | Aminopyrimidine derivatives and their use as modulators of arene receptors | 东亚ST株式会社 | 2022-11-25 | — | — | CN | disclosed |