Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 2/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764438 | 0.74 | MAPT (0.68) | MAPTHSD17B10KDM4EALDH1A1IMPDH2 | |
| SCHEMBL29606212 | 0.72 | MAPT (0.66) | MAPTHSD17B10KDM4EALDH1A1IMPDH2 | |
| SCHEMBL26133742 | 0.71 | PPIA (0.45) | MAPTHSD17B10ALDH1A1GAAPDE4D | |
| SCHEMBL3029409 | 0.71 | MAPT (0.55) | MAPTHSD17B10KDM4EALDH1A1IMPDH2 | |
| SCHEMBL28895136 | 0.70 | CYP1A2 (0.47) | MAPTHSD17B10KDM4EALDH1A1POLB | |
| SCHEMBL22271481 | 0.70 | MAPT (0.60) | MAPTHSD17B10KDM4EALDH1A1IMPDH2 | |
| SCHEMBL28895292 | 0.70 | CYP1A2 (0.50) | MAPTHSD17B10KDM4EALDH1A1POLB | |
| SCHEMBL5558567 | 0.70 | MAPT (0.61) | MAPTHSD17B10KDM4EALDH1A1POLB | |
| SCHEMBL13906680 | 0.69 | MAPT (0.62) | MAPTHSD17B10KDM4EALDH1A1IMPDH2 | |
| SCHEMBL28895242 | 0.69 | CYP1A2 (0.49) | MAPTHSD17B10KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114315805-A | Aromatic ring-fused cyclic lactone thiohydantoin compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2022-04-12 | — | — | CN | disclosed |