SCHEMBL28895205

SCHEMBL28895205

COC=Cc1c(-c2c(Cl)cccc2Cl)noc1C1CC1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 20/20 0.51
FABP1 P07148 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22790214 0.93 NR1H4 (0.46) NR1H4
SCHEMBL22790208 0.92 NR1H4 (0.45) NR1H4
SCHEMBL22789969 0.82 NR1H4 (0.47) NR1H4FABP1
SCHEMBL22790346 0.81 ALDH1A1 (0.50)
SCHEMBL28417927 0.80 NR1H4 (0.46) NR1H4FABP1
SCHEMBL20043329 0.80 NR1H4 (0.48) NR1H4FABP1
SCHEMBL20952439 0.80 NR1H4 (0.46) NR1H4FABP1
SCHEMBL22790242 0.80 PPARG (0.40) NR1H4
SCHEMBL22392710 0.77 NR1H4 (0.51) NR1H4FABP1
SCHEMBL22392584 0.77 NR1H4 (0.51) NR1H4FABP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114315844-B FXR regulator and preparation method and application thereof 中国科学院上海药物研究所 2023-06-27 CN disclosed
CN-114315844-A FXR (FXR) regulators and preparation method and application thereof 中国科学院上海药物研究所 2022-04-12 CN disclosed