Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.75 |
| ▸ | POLA1 | P09884 | 1/20 | 0.74 |
| ▸ | OSBP | P22059 | 4/20 | 0.71 |
| ▸ | RORC | P51449 | 3/20 | 0.71 |
| ▸ | USP2 | O75604 | 2/20 | 0.71 |
| ▸ | OSBP2 | Q969R2 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.71 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.62 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.61 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.61 |
| ▸ | GBA1 | P04062 | 2/20 | 0.60 |
| ▸ | UGCG | Q16739 | 2/20 | 0.60 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.60 |
| ▸ | NPC1L1 | Q9UHC9 | 4/20 | 0.59 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.59 |
| ▸ | CRYAB | P02511 | 1/20 | 0.58 |
| ▸ | HMGCR | P04035 | 1/20 | 0.58 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.58 |
| ▸ | ITGAV | P06756 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL593421 | 1.00 | CYP46A1 (0.75) | CYP46A1POLA1OSBPRORCUSP2 | |
| SCHEMBL27320611 | 1.00 | CYP46A1 (0.75) | CYP46A1POLA1OSBPRORCUSP2 | |
| SCHEMBL349479 | 1.00 | CYP46A1 (0.75) | CYP46A1POLA1OSBPRORCUSP2 | |
| SCHEMBL349478 | 1.00 | CYP46A1 (0.75) | CYP46A1POLA1OSBPRORCUSP2 | |
| SCHEMBL21879230 | 0.99 | CYP46A1 (0.74) | CYP46A1POLA1OSBPRORCUSP2 | |
| SCHEMBL15174782 | 0.99 | CYP46A1 (0.74) | CYP46A1POLA1OSBPRORCUSP2 | |
| SCHEMBL27762145 | 0.99 | CYP46A1 (0.74) | CYP46A1POLA1OSBPRORCUSP2 | |
| Dimethyl Sulfoxide SCHEMBL9614562 | 0.96 | CYP46A1 (0.70) | CYP46A1POLA1OSBPRORCUSP2 | |
| SCHEMBL14174362 | 0.94 | CYP46A1 (0.74) | CYP46A1POLA1OSBPRORCUSP2 | |
| SCHEMBL28419590 | 0.93 | CYP46A1 (0.71) | CYP46A1POLA1OSBPRORCUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117015400-A | Treatment of diseases associated with ATP-binding cassette transporter 1 dysfunction using TREM2 agonists | 维吉尔神经科学股份有限公司 | 2023-11-07 | — | — | CN | claimed |
| CN-116964454-A | Treatment of diseases associated with colony stimulating factor 1 receptor dysfunction using TREM2 agonists | 维吉尔神经科学股份有限公司 | 2023-10-27 | — | — | CN | claimed |
| CN-111448212-A | anti-TREM 2 antibodies and methods of use thereof | 戴纳立制药公司 | 2020-07-24 | — | — | CN | claimed |
| CN-118103398-A | TREM2 agonist biomarkers and methods of use thereof | 维吉尔神经科学公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-117015400-A | Treatment of diseases associated with ATP-binding cassette transporter 1 dysfunction using TREM2 agonists | 维吉尔神经科学股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-116964454-A | Treatment of diseases associated with colony stimulating factor 1 receptor dysfunction using TREM2 agonists | 维吉尔神经科学股份有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-115279790-A | anti-TREM 2 antibodies and methods of use thereof | 戴纳立制药公司 | 2022-11-01 | — | — | CN | disclosed |
| CN-113614110-A | anti-TREM 2 antibodies and methods of use thereof | 戴纳立制药公司 | 2021-11-05 | — | — | CN | disclosed |