Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 1.00 |
| ▸ | RET | P07949 | 4/20 | 1.00 |
| ▸ | SRC | P12931 | 3/20 | 1.00 |
| ▸ | EGFR | P00533 | 15/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.75 |
| ▸ | MAPT | P10636 | 3/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.75 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.75 |
| ▸ | ABL1 | P00519 | 2/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.75 |
| ▸ | FBP1 | P09467 | 2/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.75 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.75 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.75 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.75 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.75 |
| ▸ | FLT1 | P17948 | 1/20 | 0.75 |
| ▸ | CDK2 | P24941 | 1/20 | 0.75 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5483854 | 0.99 | KDR (0.97) | KDRRETSRCEGFRKDM4E | |
| SCHEMBL18158215 | 0.90 | EGFR (0.82) | KDRRETSRCEGFRKDM4E | |
| SCHEMBL3241479 | 0.90 | KDR (0.82) | KDRRETSRCEGFRKDM4E | |
| Hydrochloric Acid SCHEMBL8811926 | 0.89 | EGFR (0.80) | KDRRETSRCEGFRKDM4E | |
| SCHEMBL5864762 | 0.88 | KDR (0.78) | KDRRETSRCEGFRKDM4E | |
| SCHEMBL18158230 | 0.87 | KDR (0.77) | KDRRETSRCEGFRKDM4E | |
| SCHEMBL18158234 | 0.87 | EGFR (0.83) | KDRRETSRCEGFRKDM4E | |
| SCHEMBL18158231 | 0.87 | EGFR (0.83) | KDRRETSRCEGFRKDM4E | |
| SCHEMBL31060707 | 0.87 | EGFR (1.00) | KDRRETSRCEGFRKDM4E | |
| SCHEMBL5482883 | 0.87 | EGFR (1.00) | KDRRETSRCEGFRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513267-B2 | 4-anilinoquinazoline derivatives with adenosine-kinase inhibitor properties | UNIVERSIDADE ESTADUAL DE CAMPINAS-UNICAMP (BR) | 2013-08-20 | — | — | US | disclosed |
| EP-1737832-B1 | 4-ANILINOQUINAZOLINE DERIVATIVES WITH ADENOSINE-KINASE INHIBITORY PROPERTIES | UNICAMP (BR) | 2011-12-14 | — | — | EP | disclosed |
| US-20070060600-A1 | 4-Anilinequinazolines with adenosine-kiase inhibitor properties | UNIVERSIDADE ESTADUAL DE CAMPINAS-UNICAMP (BR) | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060600-A1 | 4-Anilinequinazolines with adenosine-kiase inhibitor properties | ADK, AK1, ADORA3 | KDR 1289/4885RET 3198/4885SRC 3276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.