Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Drospirenone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 13/20 | 0.91 |
| ▸ | NR3C2 known ✓ | P08235 | 2/20 | 0.43 |
| ▸ | AR | P10275 | 13/20 | 0.91 |
| ▸ | LMNA | P02545 | 6/20 | 0.91 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.91 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.91 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.91 |
| ▸ | HTR2B | P41595 | 2/20 | 0.91 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.91 |
| ▸ | HTR2A | P28223 | 1/20 | 0.91 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Drospirenone SCHEMBL3073676 | 0.97 | PGR (0.93) | PGRARLMNANR3C1ABCB11 | |
| Drospirenone SCHEMBL13356035 | 0.95 | PGR (1.00) | PGRARLMNANR3C1ABCB11 | |
| Drospirenone SCHEMBL18077735 | 0.95 | PGR (1.00) | PGRARLMNANR3C1ABCB11 | |
| Drospirenone SCHEMBL13460142 | 0.95 | PGR (1.00) | PGRARLMNANR3C1ABCB11 | |
| Drospirenone SCHEMBL13355946 | 0.95 | PGR (1.00) | PGRARLMNANR3C1ABCB11 | |
| Drospirenone SCHEMBL13971411 | 0.95 | PGR (1.00) | PGRARLMNANR3C1ABCB11 | |
| Drospirenone SCHEMBL14227067 | 0.95 | PGR (1.00) | PGRARLMNANR3C1ABCB11 | |
| Drospirenone SCHEMBL13015156 | 0.95 | PGR (1.00) | PGRARLMNANR3C1ABCB11 | |
| Drospirenone SCHEMBL22171517 | 0.95 | PGR (1.00) | PGRARLMNANR3C1ABCB11 | |
| Drospirenone SCHEMBL18717263 | 0.95 | PGR (1.00) | PGRARLMNANR3C1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115947681-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2023-04-11 | — | — | CN | disclosed |
| CN-109641854-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-109641844-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-11-01 | — | — | CN | disclosed |