Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 14/20 | 0.74 |
| ▸ | THRB | P10828 | 14/20 | 0.74 |
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.74 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.74 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.74 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.74 |
| ▸ | ASPH | Q12797 | 1/20 | 0.74 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.74 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.74 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Roxadustat SCHEMBL29350689 | 0.86 | THRA (1.00) | THRATHRBEGLN1BBOX1SLC6A2 | |
| Roxadustat SCHEMBL523705 | 0.86 | THRA (1.00) | THRATHRBEGLN1BBOX1SLC6A2 | |
| Roxadustat SCHEMBL29892426 | 0.86 | THRA (1.00) | THRATHRBEGLN1BBOX1SLC6A2 | |
| SCHEMBL28899786 | 0.85 | THRA (0.52) | THRATHRBEGLN1BBOX1SLC6A2 | |
| Roxadustat SCHEMBL15421351 | 0.85 | THRA (0.98) | THRATHRBEGLN1BBOX1SLC6A2 | |
| Roxadustat SCHEMBL15421446 | 0.85 | THRA (0.98) | THRATHRBEGLN1BBOX1SLC6A2 | |
| Roxadustat SCHEMBL15421357 | 0.85 | THRA (0.98) | THRATHRBEGLN1BBOX1SLC6A2 | |
| Roxadustat SCHEMBL15421135 | 0.85 | THRA (0.98) | THRATHRBEGLN1BBOX1SLC6A2 | |
| Roxadustat SCHEMBL15421447 | 0.85 | THRA (0.98) | THRATHRBEGLN1BBOX1SLC6A2 | |
| Roxadustat SCHEMBL15421137 | 0.85 | THRA (0.98) | THRATHRBEGLN1BBOX1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107382986-B | 4-hydroxy-1-methylisoquinoline derivatives and their use in increasing endogenous erythropoietin | 江苏艾立康医药科技有限公司 | 2022-09-20 | — | — | CN | disclosed |