SCHEMBL28905930

SCHEMBL28905930

O=C(O)C(O)(c1ccccc1)c1cccc(F)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 9/20 0.57
CYP2C9 P11712 2/20 0.53
CES2 O00748 1/20 0.42
CES1 P23141 1/20 0.42
CYP2D6 P10635 1/20 0.42
HIF1A Q16665 1/20 0.42
KIF11 P52732 1/20 0.41
NPC1 O15118 1/20 0.41
HPGD P15428 1/20 0.41
RAB9A P51151 1/20 0.41
CYP19A1 P11511 1/20 0.41
PLK4 O00444 1/20 0.40
DAPK3 O43293 1/20 0.40
RPS6KA5 O75582 1/20 0.40
MAP4K4 O95819 1/20 0.40
ERBB2 P04626 1/20 0.40
PRKCG P05129 1/20 0.40
PIM1 P11309 1/20 0.40
PHKG2 P15735 1/20 0.40
CDK2 P24941 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29940807 1.00 KCNN4 (0.57) KCNN4CYP2C9CES2CES1CYP2D6
SCHEMBL524825 0.96 KCNN4 (0.56) KCNN4CYP2C9CES2CES1CYP2D6
SCHEMBL29798769 0.96 KCNN4 (0.56) KCNN4CYP2C9CES2CES1CYP2D6
Bromomethane SCHEMBL207605 0.91 KCNN4 (0.51) KCNN4CYP2C9CES2CES1CYP2D6
Benzylic Acid SCHEMBL3169072 0.86 CES2 (0.65) KCNN4CYP2C9CES2CES1NPC1
Benzylic Acid SCHEMBL9181980 0.84 CYP2C9 (0.71) KCNN4CYP2C9CYP2D6HIF1ACYP1A2
SCHEMBL3227012 0.82 CYP2C9 (0.64) KCNN4CYP2C9CYP2D6HIF1AKIF11
Benzylic Acid SCHEMBL7066 0.82 CYP2C9 (0.74) KCNN4CYP2C9CYP2D6HIF1ACYP1A2
SCHEMBL12350296 0.81 PTPRC (0.49) KCNN4CES2CES1NPC1ALDH1A1
Benzylic Acid SCHEMBL11049826 0.80 CYP2C9 (0.71) KCNN4CYP2C9CYP2D6HIF1ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115108901-A Synthetic method of alpha-hydroxycarboxylic acid compound 四川大学 2022-09-27 CN disclosed