Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.61 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.61 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.48 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22886419 | 1.00 | GABRA1 (0.61) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL29877091 | 1.00 | GABRA1 (0.61) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL30272542 | 0.85 | GABRA1 (0.61) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL28906090 | 0.85 | GABRA1 (0.61) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL23947945 | 0.85 | GABRA1 (0.61) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL28906061 | 0.84 | PTPN22 (0.63) | HPGDHSD17B10L3MBTL1PTPN22 | |
| SCHEMBL22886418 | 0.80 | PTPN22 (0.79) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL25198713 | 0.79 | GABRA1 (0.65) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL28287775 | 0.78 | GABRA1 (0.71) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL22886423 | 0.78 | GABRA1 (0.74) | GABRA1GABRB2GABRB1GABRA3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118290333-A | Novel inhibitors of gonorrhoeae-specific tyrosine phosphatase (LYP) | 普渡研究基金会 | 2024-07-05 | — | — | CN | disclosed |
| CN-115461056-B | Inhibitors of Lebaba-specific tyrosine phosphatase (LYP) | 普渡研究基金会 | 2024-04-16 | — | — | CN | disclosed |
| CN-115461056-A | Novel lymphoid specific tyrosine phosphatase (LYP) inhibitors | 普渡研究基金会 | 2022-12-09 | — | — | CN | disclosed |