Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15885453 | 0.87 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2HPGDRORC | |
| SCHEMBL19768827 | 0.85 | NR1H2 (0.46) | NR1H2USP2SMN1; SMN2HPGDRORC | |
| SCHEMBL12448246 | 0.81 | NR1H2 (0.49) | NR1H2USP2SMN1; SMN2HPGDPRMT5 | |
| SCHEMBL15885747 | 0.81 | PRMT5 (0.50) | NR1H2USP2SMN1; SMN2HPGDRORC | |
| SCHEMBL21590921 | 0.79 | NR1H2 (0.44) | NR1H2USP2SMN1; SMN2HPGDRORC | |
| SCHEMBL608195 | 0.77 | NR1H2 (0.45) | NR1H2USP2SMN1; SMN2HPGDRORC | |
| SCHEMBL71275 | 0.76 | NR1H2 (0.51) | NR1H2USP2SMN1; SMN2HPGDPRMT5 | |
| SCHEMBL16419556 | 0.76 | NR1H2 (0.48) | NR1H2USP2SMN1; SMN2HPGDPRMT5 | |
| SCHEMBL10190233 | 0.76 | NR1H2 (0.50) | NR1H2USP2SMN1; SMN2HPGDRORC | |
| SCHEMBL24706864 | 0.75 | NR1H2 (0.53) | NR1H2USP2SMN1; SMN2HPGDRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115461337-A | Novel triazolyl derivatives as GABA A alpha 5 PAM | 豪夫迈·罗氏有限公司 | 2022-12-09 | — | — | CN | disclosed |