Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15885453 | 0.88 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2HPGDRORC | |
| SCHEMBL19852541 | 0.88 | USP30 (0.45) | USP2SMN1; SMN2HPGDPRMT5WDR77 | |
| SCHEMBL12448246 | 0.86 | NR1H2 (0.49) | NR1H2USP2SMN1; SMN2HPGDPRMT5 | |
| SCHEMBL28906174 | 0.85 | NR1H2 (0.45) | NR1H2USP2SMN1; SMN2HPGDRORC | |
| SCHEMBL19768828 | 0.84 | HPGD (0.50) | USP2SMN1; SMN2HPGDALDH1A1MAPT | |
| SCHEMBL21590921 | 0.84 | NR1H2 (0.44) | NR1H2USP2SMN1; SMN2HPGDRORC | |
| SCHEMBL608195 | 0.82 | NR1H2 (0.45) | NR1H2USP2SMN1; SMN2HPGDRORC | |
| SCHEMBL71275 | 0.81 | NR1H2 (0.51) | NR1H2USP2SMN1; SMN2HPGDPRMT5 | |
| SCHEMBL16419556 | 0.81 | NR1H2 (0.48) | NR1H2USP2SMN1; SMN2HPGDPRMT5 | |
| SCHEMBL21063482 | 0.80 | NR1H2 (0.43) | NR1H2USP2SMN1; SMN2HPGDPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180016227-A1 | PROCESS FOR THE SYNTHESIS OF DIFLUOROMETHYL ETHER-BASED COMPOUNDS | TRILLIUM THERAPEUTICS INC. (CA) | 2018-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180016227-A1 | PROCESS FOR THE SYNTHESIS OF DIFLUOROMETHYL ETHER-BASED COMPOUNDS | CYP2F1, CYP2E1, PAH | NR1H2 98/4885USP2 4141/4885SMN1; SMN2 1018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.