Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.30 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.30 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30138980 | 1.00 | DGAT1 (0.41) | DGAT1NPC1SMN1; SMN2GAANPSR1 | |
| SCHEMBL2471306 | 0.86 | NPC1 (0.35) | DGAT1NPC1PFKFB2PFKFB1PFKFB3 | |
| SCHEMBL31512383 | 0.83 | ELANE (0.40) | DGAT1NPC1SMN1; SMN2 | |
| SCHEMBL17849502 | 0.83 | ELANE (0.40) | DGAT1NPC1SMN1; SMN2 | |
| SCHEMBL4312796 | 0.83 | DGAT1 (0.43) | DGAT1NPC1 | |
| SCHEMBL3355074 | 0.81 | DGAT1 (0.43) | DGAT1NPC1 | |
| SCHEMBL2030421 | 0.81 | DGAT1 (0.43) | DGAT1NPC1 | |
| SCHEMBL20163415 | 0.81 | DGAT1 (0.47) | DGAT1NPC1SMN1; SMN2NPSR1 | |
| SCHEMBL14442048 | 0.81 | ELANE (0.47) | SMN1; SMN2GAA | |
| SCHEMBL23042316 | 0.81 | DGAT1 (0.44) | DGAT1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117412967-A | Methionine adenosine transferase 2A inhibitors | 南京正大天晴制药有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-115433211-A | Pyrazidopyridone methionine adenosyltransferase 2A inhibitors | 南京正大天晴制药有限公司 | 2022-12-06 | — | — | CN | disclosed |