Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | GFER | P55789 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MDM4 | O15151 | 1/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30745615 | 1.00 | HPGD (0.63) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL11657694 | 0.89 | HPGD (0.62) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7491796 | 0.87 | TUBB4A (0.61) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL28960401 | 0.87 | MDM4 (0.68) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4814649 | 0.86 | PPARG (0.67) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6929315 | 0.85 | KDM4E (0.69) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10936333 | 0.84 | HPGD (0.56) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6922498 | 0.82 | PPARG (0.66) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL12939133 | 0.81 | F2 (0.61) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL28906369 | 0.81 | MAPT (0.55) | HPGDMDM4MDM2PTGS2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115304533-B | Bisindolemethane type alpha-glucosidase inhibitor and preparation method and application thereof | 中国医学科学院药用植物研究所云南分所 | 2024-04-12 | — | — | CN | disclosed |
| CN-117567447-A | Thiophene-containing bis-indolomethane type a-glucosidase inhibitor and preparation method and application thereof | 中国医学科学院药用植物研究所云南分所 | 2024-02-20 | — | — | CN | disclosed |
| CN-115304533-A | Bis-indole methane type alpha-glucosidase inhibitor and preparation method and application thereof | 中国医学科学院药用植物研究所云南分所 | 2022-11-08 | — | — | CN | disclosed |