Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MLYCD | O95822 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2890644 | 0.87 | NTRK1 (0.63) | NTRK1MAPTALDH1A1NPSR1KDM4E | |
| SCHEMBL1912284 | 0.86 | NTRK1 (0.61) | NTRK1MAPTALDH1A1NPSR1KDM4E | |
| Trifluoroacetic Acid SCHEMBL2890639 | 0.82 | NTRK1 (0.63) | NTRK1MAPTALDH1A1NPSR1KDM4E | |
| SCHEMBL16585459 | 0.79 | NTRK1 (1.00) | NTRK1MAPTALDH1A1NPSR1KDM4E | |
| SCHEMBL17790727 | 0.78 | MAPT (0.60) | NTRK1MAPTALDH1A1NPSR1KDM4E | |
| SCHEMBL4029460 | 0.77 | NPSR1 (0.61) | NTRK1MAPTALDH1A1NPSR1KDM4E | |
| SCHEMBL18007209 | 0.77 | NTRK1 (0.74) | NTRK1MAPTALDH1A1NPSR1KDM4E | |
| SCHEMBL16585889 | 0.77 | NTRK1 (0.73) | NTRK1MAPTALDH1A1NPSR1KDM4E | |
| SCHEMBL18015478 | 0.77 | NTRK1 (1.00) | NTRK1MAPTALDH1A1NPSR1KDM4E | |
| SCHEMBL2413988 | 0.75 | HDAC1 (0.56) | NTRK1MAPTALDH1A1NPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258141-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-09-04 | — | — | US | disclosed |
| US-20100286126-A1 | Organic Compounds | NOVARTIS AG (CH) | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286126-A1 | Organic Compounds | CYP3A43, SLCO1B3, CYP2C19 | NTRK1 3668/4885MAPT 1870/4885ALDH1A1 166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.