Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4279925 | 0.94 | SCN9A (0.45) | EGFRRAF1KDRMAP2K2MAP2K1 | |
| SCHEMBL28516017 | 0.85 | BCHE (0.51) | BCHECNR2EGFRRAF1KDR | |
| SCHEMBL31402275 | 0.83 | BCHE (0.45) | BCHECNR2EGFRKDM4EPOLB | |
| SCHEMBL16065119 | 0.83 | BCHE (0.45) | BCHECNR2EGFRKDM4EPOLB | |
| SCHEMBL31402257 | 0.83 | BCHE (0.45) | BCHECNR2EGFRKDM4EPOLB | |
| SCHEMBL25304208 | 0.83 | BCHE (0.45) | BCHECNR2EGFRKDM4EPOLB | |
| SCHEMBL31402250 | 0.83 | BCHE (0.45) | BCHECNR2EGFRKDM4EPOLB | |
| SCHEMBL23720486 | 0.79 | BCHE (0.43) | BCHECNR2EGFRKDM4ESCN9A | |
| SCHEMBL24542522 | 0.79 | LMNA (0.48) | BCHECNR2EGFRRAF1KDR | |
| SCHEMBL31584155 | 0.78 | CA12 (0.60) | BCHECNR2ALDH1A1KDM4EADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112341434-B | PI3K/mTOR protein degradation targeting chimera compound and preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2021-11-26 | — | — | CN | disclosed |
| CN-112341434-A | PI3K/mTOR protein degradation targeting chimera compound and preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2021-02-09 | — | — | CN | disclosed |