Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.38 |
| ▸ | GRM5 | P41594 | 9/20 | 0.36 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2890722 | 1.00 | HCRTR1 (0.38) | HCRTR1HCRTR2GRM5SCD5HSD11B1 | |
| SCHEMBL2896283 | 0.92 | GRM5 (0.42) | HCRTR1HCRTR2GRM5HSD11B1 | |
| SCHEMBL2896290 | 0.92 | GRM5 (0.42) | HCRTR1HCRTR2GRM5HSD11B1 | |
| SCHEMBL2890599 | 0.88 | GRM5 (0.46) | HCRTR1HCRTR2GRM5SCD5PIK3C3 | |
| SCHEMBL2890593 | 0.88 | GRM5 (0.46) | HCRTR1HCRTR2GRM5SCD5PIK3C3 | |
| SCHEMBL2893687 | 0.84 | GRM5 (0.55) | HCRTR1HCRTR2GRM5SCD5 | |
| SCHEMBL2893690 | 0.84 | GRM5 (0.55) | HCRTR1HCRTR2GRM5SCD5 | |
| SCHEMBL2889894 | 0.82 | SCD (0.47) | HCRTR1HCRTR2GRM5SCD5 | |
| SCHEMBL2889899 | 0.82 | SCD (0.47) | HCRTR1HCRTR2GRM5SCD5 | |
| SCHEMBL2892678 | 0.82 | HSD11B1 (0.37) | HCRTR1HCRTR2HSD11B1PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678796-B2 | MGluR5 modulators I | ASTRAZENECA AB (SE) | 2010-03-16 | — | — | US | claimed |
| US-20070259862-A1 | MGluR5 modulators I | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | claimed |
| US-7678796-B2 | MGluR5 modulators I | ASTRAZENECA AB (SE) | 2010-03-16 | — | — | US | disclosed |
| US-20070259862-A1 | MGluR5 modulators I | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259862-A1 | MGluR5 modulators I | GRM5, GRM1, GRIK5 | HCRTR1 191/4885HCRTR2 96/4885GRM5 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.