Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 8/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2891257 | 0.94 | STAT3 (0.46) | STAT3ALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL13239798 | 0.91 | MEN1 (0.46) | STAT3ALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL2891395 | 0.90 | GRM1 (0.47) | STAT3ALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL4775176 | 0.90 | STAT3 (0.44) | STAT3ALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL2894811 | 0.89 | ALDH1A1 (0.47) | STAT3ALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL2891839 | 0.89 | GRM1 (0.47) | STAT3ALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL2887655 | 0.88 | STAT3 (0.49) | STAT3MEN1KMT2AGRM1 | |
| SCHEMBL2895828 | 0.87 | MEN1 (0.52) | STAT3ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2893526 | 0.86 | MEN1 (0.44) | STAT3ALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL4050404 | 0.85 | MEN1 (0.51) | STAT3ALDH1A1MAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100285149-A1 | NOVEL TETRAHYDROPYRIDOTHIOPHENES | 4SC AG (DE) | 2010-11-11 | — | — | US | claimed |
| US-20100285149-A1 | NOVEL TETRAHYDROPYRIDOTHIOPHENES | 4SC AG (DE) | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100285149-A1 | NOVEL TETRAHYDROPYRIDOTHIOPHENES | BAX, CCAR2, BCL2 | STAT3 461/4885ALDH1A1 566/4885MAPT 1389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.