Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 7/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | ROS1 | P08922 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FER | P16591 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28531578 | 0.89 | PARP10 (0.39) | PARP10STING1IKBKBPARP15MAOB | |
| SCHEMBL23630816 | 0.89 | STING1 (0.40) | PARP10STING1IKBKBPARP15CDC7 | |
| SCHEMBL26781813 | 0.86 | STING1 (0.43) | PARP10STING1IKBKBCDC7PLK4 | |
| SCHEMBL28531514 | 0.85 | STING1 (0.55) | STING1CDC7PLK4DYRK3ROCK2 | |
| SCHEMBL23635918 | 0.85 | ALDH1A1 (0.44) | PARP10STING1IKBKBCDC7PLK4 | |
| SCHEMBL23112222 | 0.84 | STING1 (0.52) | PARP10STING1IKBKB | |
| SCHEMBL23112070 | 0.76 | STING1 (0.53) | PARP10STING1PARP15MAOB | |
| SCHEMBL30697668 | 0.76 | STING1 (0.48) | PARP10STING1IKBKBPARP15MAOB | |
| SCHEMBL23635884 | 0.76 | STING1 (0.48) | PARP10STING1IKBKBPARP15MAOB | |
| SCHEMBL26778052 | 0.73 | STING1 (0.50) | PARP10STING1IKBKBPARP15MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112424181-B | Substituted condensed thiophenes as STING modulators | 希泰克斯特私人有限公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-112424181-A | Substituted condensed thiophenes as STING modulators | 希泰克斯特私人有限公司 | 2021-02-26 | — | — | CN | disclosed |