SCHEMBL28909207

SCHEMBL28909207

CC(C)(O)c1c(F)c(-c2ccc(F)cc2)nc(C(O)(CN(C(=O)O)C(C)(C)C)C2CC2)c1F

nearest known ligand 0.32

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CKS1B P61024 1/20 0.32
SKP1 P63208 1/20 0.32
SKP2 Q13309 1/20 0.32
PTGDR2 Q9Y5Y4 3/20 0.31
HPGDS O60760 1/20 0.31
NPC1 O15118 1/20 0.30
CASP3 P42574 1/20 0.30
RAB9A P51151 1/20 0.30
SENP8 Q96LD8 1/20 0.30
SENP7 Q9BQF6 1/20 0.30
SENP6 Q9GZR1 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
PDK2 Q15119 1/20 0.30
TNKS O95271 1/20 0.30
PARP1 P09874 1/20 0.30
TNKS2 Q9H2K2 1/20 0.30
NR3C1 P04150 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25231387 0.82 CKS1B (0.36) CKS1BSKP1SKP2HPGDSPDK2
SCHEMBL25687000 0.81 SLC34A1 (0.33) HPGDSPDK2TNKSPARP1TNKS2
SCHEMBL30007885 0.81 SLC34A1 (0.33) HPGDSPDK2TNKSPARP1TNKS2
SCHEMBL23958787 0.81 SLC34A1 (0.33) HPGDSPDK2TNKSPARP1TNKS2
SCHEMBL25686999 0.81 SLC34A1 (0.33) HPGDSPDK2TNKSPARP1TNKS2
SCHEMBL30471340 0.78 GRM2 (0.37) CKS1BSKP1SKP2PDK2
SCHEMBL23958663 0.78 GRM2 (0.37) CKS1BSKP1SKP2PDK2
SCHEMBL25234571 0.75 CKS1B (0.35) CKS1BSKP1SKP2HPGDSPDK2
SCHEMBL25691242 0.74 MAPT (0.32) CKS1BSKP1SKP2PTGDR2HPGDS
SCHEMBL30006977 0.73 SLC34A1 (0.35) NR3C1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115461336-A RSV inhibiting 3-substituted quinoline and cinnoline derivatives 爱尔兰詹森科学公司 2022-12-09 CN disclosed