Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ACP1 | P24666 | 4/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831588 | 0.81 | PDE5A (0.50) | PDE5AMEN1KMT2AACP1HCRTR1 | |
| SCHEMBL10316110 | 0.81 | ACP1 (0.58) | PDE5AMEN1KMT2AACP1HCRTR1 | |
| SCHEMBL27576034 | 0.77 | MEN1 (0.61) | PDE5AMEN1KMT2AACP1HCRTR1 | |
| SCHEMBL5806670 | 0.76 | KMT2A (0.64) | KMT2AATML3MBTL1MAPK1 | |
| SCHEMBL1085568 | 0.76 | MEN1 (0.49) | PDE5AMEN1KMT2AACP1HCRTR1 | |
| SCHEMBL13502532 | 0.75 | PRNP (0.59) | PDE5AMEN1KMT2AHCRTR1ATM | |
| SCHEMBL10674022 | 0.75 | SIRT5 (0.58) | MEN1KMT2AHCRTR1L3MBTL1ABCG2 | |
| SCHEMBL27873631 | 0.75 | ABCG2 (0.57) | PDE5AMEN1KMT2AACP1ATM | |
| SCHEMBL2640214 | 0.75 | ABCG2 (0.53) | PDE5AMEN1KMT2AACP1ATM | |
| SCHEMBL7759073 | 0.73 | PRNP (0.60) | MEN1KMT2AHCRTR1ATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106458933-B | Quinazoline scaffold-based compounds, pharmaceutical compositions thereof, and methods of use | 泰克年研究发展基金会公司 | 2021-03-05 | — | — | CN | disclosed |