Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | F13A1 | P00488 | 1/20 | 0.30 |
| ▸ | TGM2 | P21980 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23150890 | 0.84 | USP2 (0.40) | DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL21590786 | 0.80 | USP2 (0.39) | DDB1CRBNF13A1TGM2USP2 | |
| SCHEMBL21590671 | 0.75 | USP2 (0.37) | USP2SMN1; SMN2ALOX5APFEN1 | |
| SCHEMBL6914197 | 0.73 | USP2 (0.40) | DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL13661298 | 0.71 | USP2 (0.45) | DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL21590903 | 0.70 | NR1H2 (0.35) | DDB1CRBNF13A1TGM2USP2 | |
| SCHEMBL571404 | 0.70 | USP2 (0.42) | DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL570830 | 0.70 | USP2 (0.42) | DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL18696436 | 0.70 | USP2 (0.42) | USP2SMN1; SMN2ALOX5APFEN1 | |
| SCHEMBL31735249 | 0.69 | NR1H2 (0.38) | DDB1CRBNUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112424196-A | Novel isoxazolyl ether derivatives as GABAA alpha 5 PAM | 豪夫迈·罗氏有限公司 | 2021-02-26 | — | — | CN | disclosed |