Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.44 |
| ▸ | RET | P07949 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 3/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | PAK4 | O96013 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.43 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30379613 | 1.00 | SYK (0.44) | SYKRETFLT3RPS6KA3JAK2 | |
| SCHEMBL28546939 | 0.89 | TTK (0.43) | SYKRETFLT3RPS6KA3JAK2 | |
| SCHEMBL21596331 | 0.86 | FGFR1 (0.53) | RETFLT3RPS6KA3JAK2CSF1R | |
| SCHEMBL28537285 | 0.85 | WEE1 (0.53) | SYKRETFLT3RPS6KA3JAK2 | |
| SCHEMBL30379743 | 0.85 | WEE1 (0.53) | SYKRETFLT3RPS6KA3JAK2 | |
| SCHEMBL21600933 | 0.83 | FGFR1 (0.43) | SYKRETFLT3RPS6KA3JAK2 | |
| SCHEMBL21596362 | 0.82 | TTK (0.57) | RETFLT3RPS6KA3JAK2CSF1R | |
| SCHEMBL30379442 | 0.81 | SYK (0.50) | SYKRETFLT3RPS6KA3JAK2 | |
| SCHEMBL28953581 | 0.80 | SYK (0.49) | SYKRETFLT3RPS6KA3JAK2 | |
| SCHEMBL30379741 | 0.78 | JAK2 (0.44) | SYKRETFLT3RPS6KA3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |