Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28910563 | 0.86 | SLC2A1 (0.48) | SYKLRRK2SLC2A1PKMYT1AURKA | |
| SCHEMBL21596311 | 0.85 | MAPK3 (0.46) | SYKJAK2JAK3 | |
| SCHEMBL28531632 | 0.85 | FGFR1 (0.47) | SYKLRRK2SLC2A1AURKAMAP4K4 | |
| SCHEMBL28953570 | 0.81 | PKMYT1 (0.49) | SYKLRRK2SLC2A1PKMYT1AURKA | |
| SCHEMBL28546937 | 0.81 | JAK3 (0.47) | LRRK2PKMYT1JAK2JAK3 | |
| SCHEMBL30379613 | 0.80 | SYK (0.44) | SYKLRRK2SLC2A1AURKADAPK3 | |
| SCHEMBL28910559 | 0.80 | SYK (0.44) | SYKLRRK2SLC2A1AURKADAPK3 | |
| SCHEMBL30379442 | 0.79 | SYK (0.50) | SYKLRRK2AURKADAPK3JAK2 | |
| SCHEMBL28953583 | 0.76 | EGFR (0.49) | LRRK2SLC2A1PKMYT1AURKAIGF1R | |
| SCHEMBL30379391 | 0.74 | LRRK2 (0.49) | SYKLRRK2SLC2A1PKMYT1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |