Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.77 |
| ▸ | KDR | P35968 | 4/20 | 0.77 |
| ▸ | GAK | O14976 | 1/20 | 0.77 |
| ▸ | ACOX3 | O15254 | 1/20 | 0.77 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.77 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.77 |
| ▸ | EGFR | P00533 | 1/20 | 0.77 |
| ▸ | ESR1 | P03372 | 1/20 | 0.77 |
| ▸ | PGR | P06401 | 1/20 | 0.77 |
| ▸ | RET | P07949 | 1/20 | 0.77 |
| ▸ | ROS1 | P08922 | 1/20 | 0.77 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.77 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.77 |
| ▸ | FER | P16591 | 1/20 | 0.77 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.77 |
| ▸ | DRD1 | P21728 | 1/20 | 0.77 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.77 |
| ▸ | PDE4A | P27815 | 1/20 | 0.77 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.77 |
| ▸ | DRD3 | P35462 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22056011 | 0.94 | ALK (0.80) | ALKKDRGAKACOX3NR1I2 | |
| SCHEMBL20004241 | 0.90 | ALK (0.83) | ALKKDRGAKACOX3NR1I2 | |
| SCHEMBL898196 | 0.89 | ALK (0.79) | ALKKDRGAKACOX3NR1I2 | |
| SCHEMBL1756022 | 0.89 | ALK (0.79) | ALKKDRGAKACOX3NR1I2 | |
| SCHEMBL29940275 | 0.89 | ALK (0.79) | ALKKDRGAKACOX3NR1I2 | |
| SCHEMBL1755912 | 0.88 | ALK (0.80) | ALKKDRGAKACOX3NR1I2 | |
| SCHEMBL30622252 | 0.88 | ALK (0.77) | ALKKDRGAKACOX3NR1I2 | |
| SCHEMBL18560105 | 0.87 | ALK (0.76) | ALKKDRGAKACOX3NR1I2 | |
| SCHEMBL10283148 | 0.87 | ALK (0.76) | ALKKDRGAKACOX3NR1I2 | |
| Alectinib SCHEMBL18631602 | 0.87 | ALK (1.00) | ALKKDRGAKACOX3NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115340523-B | Compound with ALK inhibitory activity and preparation method and application thereof | 盛世泰科生物医药技术(苏州)股份有限公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-115340523-A | Compound with ALK inhibitory activity and preparation method and application thereof | 盛世泰科生物医药技术(苏州)有限公司 | 2022-11-15 | — | — | CN | disclosed |