Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 1.00 |
| ▸ | DRD2 | P14416 | 3/20 | 0.60 |
| ▸ | DRD3 | P35462 | 3/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.51 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.50 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28917645 | 0.99 | LTA4H (0.97) | LTA4HDRD2DRD3PDGFRBPDGFRA | |
| SCHEMBL31159472 | 0.92 | LTA4H (0.85) | LTA4HDRD2DRD3HRH3 | |
| SCHEMBL17384760 | 0.91 | LTA4H (0.84) | LTA4HDRD2DRD3HRH3PSMB1 | |
| SCHEMBL4125652 | 0.88 | LTA4H (0.78) | LTA4HDRD2DRD3PDGFRBPDGFRA | |
| SCHEMBL20435503 | 0.81 | LTA4H (0.65) | LTA4HDRD2DRD3PDGFRBPDGFRA | |
| SCHEMBL7144131 | 0.80 | LTA4H (0.65) | LTA4HDRD2DRD3HRH3 | |
| SCHEMBL16826343 | 0.79 | LTA4H (0.64) | LTA4HDRD2DRD3PRKCQ | |
| SCHEMBL21068020 | 0.78 | LTA4H (0.64) | LTA4HDRD2DRD3PDGFRBPDGFRA | |
| SCHEMBL31159413 | 0.78 | LTA4H (0.64) | LTA4HDRD2DRD3PRKCQHRH3 | |
| SCHEMBL1267643 | 0.78 | LTA4H (0.64) | LTA4HPRKCQHRH3PSMB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110229091-B | 1, 5-disubstituted indole derivatives with leukotriene A4 hydrolase inhibition effect and application thereof | 天津科技大学 | 2022-11-22 | — | — | CN | disclosed |