SCHEMBL28918896

SCHEMBL28918896

CCOP(=O)(COC[C@H]1O[C@H](Cn2ncc3c(NC4CCCC4)nc(Cl)nc32)[C@@H]2OC(C)(C)O[C@@H]21)OCC

nearest known ligand 0.51

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
NT5E P21589 20/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28594152 0.90 NT5E (0.63) NT5E
SCHEMBL22281835 0.90 NT5E (0.50) NT5E
SCHEMBL20524218 0.89 NT5E (0.61) NT5E
SCHEMBL24672312 0.83 ADORA3 (0.47) NT5E
SCHEMBL30008091 0.83 ADORA3 (0.47) NT5E
SCHEMBL28591762 0.83 ADORA3 (0.47) NT5E
SCHEMBL21882851 0.82 NT5E (0.48) NT5E
SCHEMBL30394489 0.82 NT5E (0.48) NT5E
SCHEMBL24672311 0.82 NT5E (0.45) NT5E
SCHEMBL21840057 0.82 NT5E (0.56) NT5E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112955444-A Novel small-molecule CD73 inhibitor, preparation method thereof and application thereof in medicine 江苏恒瑞医药股份有限公司 2021-06-11 CN disclosed