Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 3/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | GRM8 | O00222 | 1/20 | 0.37 |
| ▸ | GRM6 | O15303 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GSR | P00390 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.37 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamine SCHEMBL27137479 | 0.94 | ALOX15 (0.37) | SLC1A3SLC1A2SLC1A1SLC7A5GRM8 | |
| Glutamic Acid SCHEMBL7654784 | 0.92 | GRM8 (0.44) | SLC1A3SLC1A2SLC1A1GRM8GRM6 | |
| D-Glutamate SCHEMBL27639981 | 0.92 | GRM8 (0.44) | SLC1A3SLC1A2SLC1A1GRM8GRM6 | |
| D-Glutamate SCHEMBL22833968 | 0.90 | SLC1A3 (0.45) | SLC1A3SLC1A2SLC1A1SLC7A5GRM8 | |
| Leucine SCHEMBL27660747 | 0.89 | SLC7A5 (0.46) | SLC1A3SLC1A2SLC1A1SLC7A5REN | |
| Leucine SCHEMBL6463330 | 0.89 | SLC7A5 (0.46) | SLC1A3SLC1A2SLC1A1SLC7A5REN | |
| D-Glutamate SCHEMBL27532423 | 0.89 | GRM8 (0.35) | SLC1A3SLC1A2SLC1A1GRM8GRM6 | |
| Lysine SCHEMBL28505796 | 0.89 | GSR (0.32) | GSR | |
| Lysine SCHEMBL28499880 | 0.89 | GSR (0.32) | GSR | |
| Lysine SCHEMBL28513393 | 0.89 | GSR (0.32) | GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112535738-B | Oxaliplatin conjugate and preparation method and application thereof | 中国科学技术大学 | 2022-09-09 | — | — | CN | disclosed |
| CN-112535738-A | Oxaliplatin conjugate and preparation method and application thereof | 中国科学技术大学 | 2021-03-23 | — | — | CN | disclosed |