Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29395253 | 0.83 | AAK1 (0.46) | LMNAPOLBRXFP1SMN1; SMN2HTT | |
| SCHEMBL25159676 | 0.83 | AAK1 (0.46) | LMNAPOLBRXFP1SMN1; SMN2HTT | |
| SCHEMBL19502094 | 0.82 | LMNA (0.44) | LMNAPOLBRXFP1NOTUMSMN1; SMN2 | |
| SCHEMBL879697 | 0.82 | NOTUM (0.46) | LMNANOTUMSMN1; SMN2CFTRMAPT | |
| SCHEMBL30369522 | 0.81 | CA12 (0.38) | RXFP1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL27877831 | 0.76 | LMNA (0.43) | LMNAPOLBRXFP1NOTUMSMN1; SMN2 | |
| SCHEMBL25894537 | 0.75 | NOTUM (0.51) | LMNAPOLBRXFP1NOTUMSMN1; SMN2 | |
| SCHEMBL25894469 | 0.75 | MAPT (0.58) | LMNAPOLBRXFP1SMN1; SMN2MAPT | |
| SCHEMBL24427638 | 0.75 | LMNA (0.51) | LMNAPOLBRXFP1SMN1; SMN2MAPT | |
| SCHEMBL16801310 | 0.74 | AAK1 (0.46) | RXFP1SMN1; SMN2NPC1RAB9AAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115490709-A | KRASG12D inhibitor and application thereof in medicine | 四川海思科制药有限公司 | 2022-12-20 | — | — | CN | disclosed |