Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL503659 | 1.00 | SLC7A5 (0.43) | SLC7A5CYP3A4CYP1A2PTPRCALPI | |
| Histidine SCHEMBL503658 | 1.00 | SLC7A5 (0.43) | SLC7A5CYP3A4CYP1A2PTPRCALPI | |
| Histidine SCHEMBL15670767 | 1.00 | SLC7A5 (0.43) | SLC7A5CYP3A4CYP1A2PTPRCALPI | |
| Histidine SCHEMBL17337984 | 0.98 | SLC7A5 (0.42) | SLC7A5CYP3A4CYP1A2PTPRCALPI | |
| Histidine SCHEMBL11670059 | 0.98 | SLC7A5 (0.42) | SLC7A5CYP3A4CYP1A2PTPRCALPI | |
| Histidine SCHEMBL11670058 | 0.98 | SLC7A5 (0.42) | SLC7A5CYP3A4CYP1A2PTPRCALPI | |
| Histidine SCHEMBL11670811 | 0.96 | SLC7A5 (0.40) | SLC7A5CYP3A4CYP1A2PTPRCALPI | |
| Histidine SCHEMBL29915024 | 0.96 | SLC7A5 (0.40) | SLC7A5CYP3A4CYP1A2PTPRCALPI | |
| Histidine SCHEMBL11670808 | 0.96 | SLC7A5 (0.40) | SLC7A5CYP3A4CYP1A2PTPRCALPI | |
| Histidine SCHEMBL11670599 | 0.94 | SLC7A5 (0.41) | SLC7A5CYP3A4CYP1A2PTPRCALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115552013-A | Modified micronucleus core proteins and their use in nucleic acid delivery | 加总生物公司 | 2022-12-30 | — | — | CN | disclosed |