⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL487378 | 0.97 | SOS1 (0.30) | — | |
| Iodide SCHEMBL1885520 | 0.94 | — | — | |
| Hydrochloric Acid SCHEMBL28491334 | 0.94 | — | — | |
| SCHEMBL28998095 | 0.89 | SOS1 (0.33) | — | |
| SCHEMBL29248112 | 0.82 | SOS1 (0.31) | — | |
| Carbamic Acid SCHEMBL28512806 | 0.82 | PARP1 (0.33) | — | |
| SCHEMBL28373752 | 0.80 | DNM1 (0.32) | — | |
| SCHEMBL10697678 | 0.79 | — | — | |
| Methacrylic Acid SCHEMBL28395192 | 0.77 | TSHR (0.31) | — | |
| Methyl Carbamate SCHEMBL28512803 | 0.77 | USP2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117015536-A | 2- (indazol-5-yl) -6- (piperidin-4-yl) -1, 7-naphthyridine derivatives and related compounds as modulators of nucleic acid splicing and treatment of proliferative diseases | 雷密克斯医疗公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-116997548-A | HTT modulators for the treatment of huntington's disease | CHDI基金会股份有限公司 | 2023-11-03 | — | — | CN | disclosed |
| CN-116940578-A | 5- [5- (piperidin-4-yl) thieno [3,2-C ] pyrazol-2-yl ] indazole derivatives and related compounds as modulators for splicing nucleic acids and for the treatment of proliferative diseases | 雷密克斯医疗公司 | 2023-10-24 | — | — | CN | disclosed |
| CN-116134036-A | Compounds and methods for modulating splicing | 雷密克斯医疗公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-115551847-A | Pyridazine derivatives for modulating nucleic acid splicing | 雷密克斯医疗公司 | 2022-12-30 | — | — | CN | disclosed |
| CN-115551843-A | Pyridazine derivatives for modulating nucleic acid splicing | 雷密克斯医疗公司 | 2022-12-30 | — | — | CN | disclosed |
| CN-115485025-A | Compounds and methods for modulating splicing | 雷密克斯医疗公司 | 2022-12-16 | — | — | CN | disclosed |
| CN-115485023-A | Compounds and methods for modulating splicing | 雷密克斯医疗公司 | 2022-12-16 | — | — | CN | disclosed |