SCHEMBL28926331

SCHEMBL28926331

O=C(OC(c1ccccc1)(c1ccccc1)c1ccccc1)C(c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 9/20 0.61
NPSR1 Q6W5P4 2/20 0.41
CYP2C19 P33261 1/20 0.41
HIF1A Q16665 1/20 0.41
CYP1A2 P05177 2/20 0.40
KMT2A Q03164 2/20 0.40
MEN1 O00255 1/20 0.40
CYP2D6 P10635 1/20 0.38
MAPT P10636 1/20 0.38
CES1 P23141 1/20 0.37
KIF11 P52732 1/20 0.36
ALDH1A1 P00352 1/20 0.35
ALOX15 P16050 1/20 0.35
HDAC3 O15379 1/20 0.35
HDAC4 P56524 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC7 Q8WUI4 1/20 0.35
HDAC2 Q92769 1/20 0.35
HDAC10 Q969S8 1/20 0.35
HDAC11 Q96DB2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25068222 0.81 KCNN4 (0.48) KCNN4CYP2C19HIF1ACYP1A2KMT2A
Hydrogen Peroxide SCHEMBL27880626 0.81 KCNN4 (0.64) KCNN4NPSR1CYP2C19HIF1ACYP1A2
SCHEMBL10857550 0.81 KCNN4 (0.44) KCNN4CYP2C19HIF1ACYP1A2KMT2A
SCHEMBL491371 0.81 KCNN4 (0.64) KCNN4NPSR1CYP2C19HIF1ACYP1A2
SCHEMBL7587514 0.79 KCNN4 (0.68) KCNN4NPSR1CYP2C19HIF1ACYP1A2
SCHEMBL8746377 0.79 KCNN4 (0.45) KCNN4NPSR1CYP2C19HIF1ACYP1A2
SCHEMBL14935466 0.79 KCNN4 (0.45) KCNN4NPSR1CYP2C19HIF1ACYP1A2
SCHEMBL2442870 0.79 KCNN4 (0.45) KCNN4NPSR1CYP2C19HIF1ACYP1A2
Hydrogen Sulfide SCHEMBL27788757 0.79 KCNN4 (0.62) KCNN4NPSR1CYP2C19HIF1ACYP1A2
Water SCHEMBL27886592 0.79 KCNN4 (0.62) KCNN4NPSR1CYP2C19HIF1ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115381774-A Pharmaceutical formulation comprising a combination of a long-acting inhaled steroid and a long-acting beta 2 receptor agonist 立生医药(苏州)有限公司 2022-11-25 CN disclosed