Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 10/20 | 0.43 |
| ▸ | CTSK | P43235 | 6/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | SDCBP | O00560 | 1/20 | 0.34 |
| ▸ | SDC2 | P34741 | 1/20 | 0.34 |
| ▸ | UGCG | Q16739 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | PRF1 | P14222 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL299705 | 0.80 | CTSC (0.51) | CTSCCTSKPIK3CAMTORSDCBP | |
| SCHEMBL2890645 | 0.78 | CTSC (0.68) | CTSCCTSK | |
| SCHEMBL289266 | 0.78 | CTSC (0.47) | CTSCCTSKPIK3CAMTORSDCBP | |
| SCHEMBL290587 | 0.77 | TACR2 (0.32) | — | |
| SCHEMBL298896 | 0.74 | CTSC (0.59) | CTSCCTSKSDCBPSDC2 | |
| SCHEMBL2892971 | 0.70 | CTSC (0.48) | CTSCCTSKSDCBPSDC2UGCG | |
| SCHEMBL2892969 | 0.70 | CTSC (0.48) | CTSCCTSKSDCBPSDC2UGCG | |
| SCHEMBL2890558 | 0.68 | CTSC (0.62) | CTSCCTSK | |
| SCHEMBL2890557 | 0.68 | CTSC (0.62) | CTSCCTSK | |
| SCHEMBL299126 | 0.68 | CTSC (0.43) | CTSCCTSKSDCBPSDC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427445-A1 | SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 | AstraZeneca AB (SE) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128324-A1 | SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 | ASTRAZENECA AB (SE) | 2010-11-11 | — | — | WO | disclosed |