Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Zucapsaicin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 known ✓ | Q8NER1 | 10/20 | 0.90 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.90 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.90 |
| ▸ | MAPT | P10636 | 3/20 | 0.90 |
| ▸ | MEN1 | O00255 | 2/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.90 |
| ▸ | TP53 | P04637 | 2/20 | 0.90 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.90 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.90 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.90 |
| ▸ | KDM1A | O60341 | 1/20 | 0.90 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.90 |
| ▸ | LMNA | P02545 | 1/20 | 0.90 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.90 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.90 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.90 |
| ▸ | HTR2C | P28335 | 1/20 | 0.90 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Capsaicin SCHEMBL28114637 | 1.00 | TRPV1 (0.90) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL1155584 | 0.96 | TRPV1 (0.83) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL1155587 | 0.96 | TRPV1 (0.83) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL3397147 | 0.96 | TRPV1 (0.83) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL3397142 | 0.96 | TRPV1 (0.83) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL16309566 | 0.96 | TRPV1 (0.98) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL31182202 | 0.96 | TRPV1 (0.98) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL1878911 | 0.96 | TRPV1 (0.98) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL1878909 | 0.96 | TRPV1 (0.98) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL29819433 | 0.96 | TRPV1 (0.98) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427056-A1 | METHODS OF PREVENTING ISCHEMIC INJURY USING PERIPHERAL NOCICEPTIVE STIMULATION | University Of Cincinnati (US) | 2012-03-14 | — | — | EP | claimed |
| WO-2010129845-A1 | METHODS OF PREVENTING ISCHEMIC INJURY USING PERIPHERAL NOCICEPTIVE STIMULATION | UNIVERSITY OF CINCINNATI (US) | 2010-11-11 | — | — | WO | claimed |