Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Capsaicin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 known ✓ | Q8NER1 | 9/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.83 |
| ▸ | MAPT | P10636 | 3/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.83 |
| ▸ | MEN1 | O00255 | 2/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.83 |
| ▸ | TP53 | P04637 | 2/20 | 0.83 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.83 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.83 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.83 |
| ▸ | KDM1A | O60341 | 1/20 | 0.83 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.83 |
| ▸ | LMNA | P02545 | 1/20 | 0.83 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.83 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.83 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.83 |
| ▸ | HTR2C | P28335 | 1/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Capsaicin SCHEMBL3397147 | 1.00 | TRPV1 (0.83) | TRPV1CYP1A2CYP3A4ALDH1A1MAPT | |
| Capsaicin SCHEMBL3397142 | 1.00 | TRPV1 (0.83) | TRPV1CYP1A2CYP3A4ALDH1A1MAPT | |
| Capsaicin SCHEMBL1155584 | 1.00 | TRPV1 (0.83) | TRPV1CYP1A2CYP3A4ALDH1A1MAPT | |
| Zucapsaicin SCHEMBL289300 | 0.96 | TRPV1 (0.90) | TRPV1CYP1A2CYP3A4ALDH1A1MAPT | |
| Capsaicin SCHEMBL28114637 | 0.96 | TRPV1 (0.90) | TRPV1CYP1A2CYP3A4ALDH1A1MAPT | |
| Capsaicin SCHEMBL1757933 | 0.94 | TRPV1 (0.86) | TRPV1CYP1A2CYP3A4ALDH1A1MAPT | |
| Capsaicin SCHEMBL1757936 | 0.94 | TRPV1 (0.86) | TRPV1CYP1A2CYP3A4ALDH1A1MAPT | |
| SCHEMBL16309566 | 0.92 | TRPV1 (0.98) | TRPV1CYP1A2CYP3A4ALDH1A1MAPT | |
| SCHEMBL31182202 | 0.92 | TRPV1 (0.98) | TRPV1CYP1A2CYP3A4ALDH1A1MAPT | |
| SCHEMBL1878911 | 0.92 | TRPV1 (0.98) | TRPV1CYP1A2CYP3A4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260115155-A1 | STABLE FORMS OF CAPSAICIN PALMITATE FOR THE TREATMENT OF PAIN | CHORDA PHARMA INC (US) | 2026-04-30 | — | — | US | claimed |
| EP-4733295-A1 | STABLE FORMS OF CAPSAICIN PALMITATE FOR THE TREATMENT OF PAIN | Chorda Pharma, Inc. (US) | 2026-04-29 | — | — | EP | claimed |
| US-12458611-B1 | Stable forms of capsaicin palmitate for the treatment of pain | CHORDA PHARMA, INC. (US) | 2025-11-04 | — | — | US | claimed |
| US-20220168259-A1 | CHEMICAL DERIVATIVES AND METHODS FOR SYNTHESIZING AND COMPOUNDING CHEMICAL DERIVATIVES RELATED TO CAPSAICIN PALMITATE AND CAPSAICIN PRODRUGS | CHORDA PHARMA, INC. | 2022-06-02 | — | — | US | claimed |
| WO-2021034863-A1 | CHEMICAL DERIVATIVES AND METHODS FOR SYNTHESIZING AND COMPOUNDING CHEMICAL DERIVATIVES RELATED TO CAPSAICIN PALMITATE AND CAPSAICIN PRODRUGS | CHORDA PHARMA, INC. (US) | 2021-02-25 | — | — | WO | claimed |
| US-8987328-B2 | Esters of capsaicinoids as dietary supplements | TRINITY LABORATORIES, INC. (US) | 2015-03-24 | — | — | US | claimed |
| US-8765807-B2 | Esters of capsaicin for treating pain | TRINITY LABORATORIES, INC. (US) | 2014-07-01 | — | — | US | claimed |
| US-20140134261-A1 | Pharmaceutical Compositions Comprising Capsaicin Esters for Treating Pain and Cold Sores | TRINITY LABORATORIES, INC. (US) | 2014-05-15 | — | — | US | claimed |
| US-20130189354-A1 | Novel Pharmaceutical Compositions for Treating Chronic Pain and Pain Associated with Neuropathy | Trinity Laboratories, Inc., (US) | 2013-07-25 | — | — | US | claimed |
| WO-2012048294-A2 | PHARMACEUTICAL COMPOSITIONS FOR TREATING CHRONIC PAIN AND PAIN ASSOCIATED WITH NEUROPATHY | TRINITY LABORATORIES, INC. (US) | 2012-04-12 | — | — | WO | claimed |
| US-7943666-B2 | Esters of capsaicin for treating pain | TRINITY LABORATORIES, INC. (US) | 2011-05-17 | — | — | US | claimed |
| US-20110039875-A1 | PHARAMACEUTICAL COMPOSITIONS FOR TREATING CHRONIC PAIN AND PAIN ASSOCIATED WITH NEUROPATHY | TRINITY LABORATORIES, INC. | 2011-02-17 | — | — | US | claimed |
| EP-2184986-A2 | PHARMACEUTICAL COMPOSITIONS FOR TREATING CHRONIC PAIN AND PAIN ASSOCIATED WITH NEUROPATHY | Trinity Laboratories, Inc. (US) | 2010-05-19 | — | — | EP | claimed |
| US-20100120780-A1 | TREATMENTS FOR PREMATURE EJACULATION IN HUMANS | TRINITY LABORATORIES INC. | 2010-05-13 | — | — | US | claimed |
| US-20100120912-A1 | Esters of capsaicinoids as dietary supplements | TRINITY LABORATORIES INC. (US) | 2010-05-13 | — | — | US | claimed |
| US-7645767-B2 | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy | TRINITY LABORATORIES, INC. (US) | 2010-01-12 | — | — | US | claimed |
| WO-2009021058-A2 | PHARMACEUTICAL COMPOSITIONS FOR TREATING CHRONIC PAIN AND PAIN ASSOCIATED WITH NEUROPATHY | TRINITY LABORTORIES, INC. (US) | 2009-02-12 | — | — | WO | claimed |
| WO-2008131256-A1 | IMPROVED TREATMENTS FOR PREMATURE EJACULATION IN HUMANS | TRINITY LABORATORIES INC. (US) | 2008-10-30 | — | — | WO | claimed |
| US-20080058362-A1 | Novel pharmaceutical compositions for treating chronic pain and pain associated with neuropathy | JEFFERSON BANK | 2008-03-06 | — | — | US | claimed |
| US-20260115155-A1 | STABLE FORMS OF CAPSAICIN PALMITATE FOR THE TREATMENT OF PAIN | CHORDA PHARMA INC (US) | 2026-04-30 | — | — | US | disclosed |
| US-20260115155-A1 | STABLE FORMS OF CAPSAICIN PALMITATE FOR THE TREATMENT OF PAIN | CHORDA PHARMA INC (US) | 2026-04-30 | — | — | US | disclosed |
| EP-4733295-A1 | STABLE FORMS OF CAPSAICIN PALMITATE FOR THE TREATMENT OF PAIN | Chorda Pharma, Inc. (US) | 2026-04-29 | — | — | EP | disclosed |
| EP-4733295-A1 | STABLE FORMS OF CAPSAICIN PALMITATE FOR THE TREATMENT OF PAIN | Chorda Pharma, Inc. (US) | 2026-04-29 | — | — | EP | disclosed |
| US-12458611-B1 | Stable forms of capsaicin palmitate for the treatment of pain | CHORDA PHARMA, INC. (US) | 2025-11-04 | — | — | US | disclosed |
| US-12458611-B1 | Stable forms of capsaicin palmitate for the treatment of pain | CHORDA PHARMA, INC. (US) | 2025-11-04 | — | — | US | disclosed |
| CN-120447159-B | Nonmetal fireproof rat-proof termite-proof optical cable and processing method thereof | 深圳市特发信息股份有限公司 | 2025-09-19 | — | — | CN | disclosed |
| CN-120447159-A | Nonmetal fireproof rat-proof termite-proof optical cable and processing method thereof | 深圳市特发信息股份有限公司 | 2025-08-08 | — | — | CN | disclosed |
| US-12358868-B2 | Chemical derivatives and methods for synthesizing and compounding chemical derivatives related to capsaicin palmitate and capsaicin prodrugs | CHORDA PHARMA, INC. (US) | 2025-07-15 | — | — | US | disclosed |
| US-12358868-B2 | Chemical derivatives and methods for synthesizing and compounding chemical derivatives related to capsaicin palmitate and capsaicin prodrugs | CHORDA PHARMA, INC. (US) | 2025-07-15 | — | — | US | disclosed |
| WO-2024243507-A3 | SOLID FORMS OF CAPSAICIN PALMITATE FOR THE TREATMENT OF PAIN | CHORDA PHARMA, INC. (US) | 2025-04-24 | — | — | WO | disclosed |
| WO-2024243507-A2 | SOLID FORMS OF CAPSAICIN PALMITATE FOR THE TREATMENT OF PAIN | CHORDA PHARMA, INC. (US) | 2024-11-28 | — | — | WO | disclosed |
| WO-2024243507-A2 | SOLID FORMS OF CAPSAICIN PALMITATE FOR THE TREATMENT OF PAIN | CHORDA PHARMA, INC. (US) | 2024-11-28 | — | — | WO | disclosed |
| US-20230406816-A1 | CHEMICAL DERIVATIVES AND METHODS FOR SYNTHESIZING AND COMPOUNDING CHEMICAL DERIVATIVES RELATED TO CAPSAICIN PALMITATE AND CAPSAICIN PRODRUGS | CHORDA PHARMA INC (US) | 2023-12-21 | — | — | US | disclosed |
| US-20230406816-A1 | CHEMICAL DERIVATIVES AND METHODS FOR SYNTHESIZING AND COMPOUNDING CHEMICAL DERIVATIVES RELATED TO CAPSAICIN PALMITATE AND CAPSAICIN PRODRUGS | CHORDA PHARMA INC (US) | 2023-12-21 | — | — | US | disclosed |
| US-11773055-B2 | Chemical derivatives and methods for synthesizing and compounding chemical derivatives related to capsaicin palmitate and capsaicin prodrugs | CHORDA PHARMA, INC. (US) | 2023-10-03 | — | — | US | disclosed |
| US-11773055-B2 | Chemical derivatives and methods for synthesizing and compounding chemical derivatives related to capsaicin palmitate and capsaicin prodrugs | CHORDA PHARMA, INC. (US) | 2023-10-03 | — | — | US | disclosed |
| US-20220168259-A1 | CHEMICAL DERIVATIVES AND METHODS FOR SYNTHESIZING AND COMPOUNDING CHEMICAL DERIVATIVES RELATED TO CAPSAICIN PALMITATE AND CAPSAICIN PRODRUGS | CHORDA PHARMA, INC. | 2022-06-02 | — | — | US | disclosed |
| US-20220168259-A1 | CHEMICAL DERIVATIVES AND METHODS FOR SYNTHESIZING AND COMPOUNDING CHEMICAL DERIVATIVES RELATED TO CAPSAICIN PALMITATE AND CAPSAICIN PRODRUGS | CHORDA PHARMA, INC. | 2022-06-02 | — | — | US | disclosed |
| WO-2021034863-A1 | CHEMICAL DERIVATIVES AND METHODS FOR SYNTHESIZING AND COMPOUNDING CHEMICAL DERIVATIVES RELATED TO CAPSAICIN PALMITATE AND CAPSAICIN PRODRUGS | CHORDA PHARMA, INC. (US) | 2021-02-25 | — | — | WO | disclosed |
| WO-2021034863-A1 | CHEMICAL DERIVATIVES AND METHODS FOR SYNTHESIZING AND COMPOUNDING CHEMICAL DERIVATIVES RELATED TO CAPSAICIN PALMITATE AND CAPSAICIN PRODRUGS | CHORDA PHARMA, INC. (US) | 2021-02-25 | — | — | WO | disclosed |
| US-10300031-B2 | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy | TRINITY LABORATORIES INC. (US) | 2019-05-28 | — | — | US | disclosed |
| US-8987328-B2 | Esters of capsaicinoids as dietary supplements | TRINITY LABORATORIES, INC. (US) | 2015-03-24 | — | — | US | disclosed |
| US-8765807-B2 | Esters of capsaicin for treating pain | TRINITY LABORATORIES, INC. (US) | 2014-07-01 | — | — | US | disclosed |
| US-20140134261-A1 | Pharmaceutical Compositions Comprising Capsaicin Esters for Treating Pain and Cold Sores | TRINITY LABORATORIES, INC. (US) | 2014-05-15 | — | — | US | disclosed |
| US-20130189354-A1 | Novel Pharmaceutical Compositions for Treating Chronic Pain and Pain Associated with Neuropathy | Trinity Laboratories, Inc., (US) | 2013-07-25 | — | — | US | disclosed |
| WO-2012048294-A2 | PHARMACEUTICAL COMPOSITIONS FOR TREATING CHRONIC PAIN AND PAIN ASSOCIATED WITH NEUROPATHY | TRINITY LABORATORIES, INC. (US) | 2012-04-12 | — | — | WO | disclosed |
| US-20110218180-A1 | Esters of Capsaicin for Treating Pain | Trinity Laboratiories, Inc. (US) | 2011-09-08 | — | — | US | disclosed |
| US-7943666-B2 | Esters of capsaicin for treating pain | TRINITY LABORATORIES, INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-20110039875-A1 | PHARAMACEUTICAL COMPOSITIONS FOR TREATING CHRONIC PAIN AND PAIN ASSOCIATED WITH NEUROPATHY | TRINITY LABORATORIES, INC. | 2011-02-17 | — | — | US | disclosed |
| EP-2184986-A2 | PHARMACEUTICAL COMPOSITIONS FOR TREATING CHRONIC PAIN AND PAIN ASSOCIATED WITH NEUROPATHY | Trinity Laboratories, Inc. (US) | 2010-05-19 | — | — | EP | disclosed |
| US-20100120780-A1 | TREATMENTS FOR PREMATURE EJACULATION IN HUMANS | TRINITY LABORATORIES INC. | 2010-05-13 | — | — | US | disclosed |
| US-20100120912-A1 | Esters of capsaicinoids as dietary supplements | TRINITY LABORATORIES INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-7645767-B2 | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy | TRINITY LABORATORIES, INC. (US) | 2010-01-12 | — | — | US | disclosed |
| WO-2009021058-A2 | PHARMACEUTICAL COMPOSITIONS FOR TREATING CHRONIC PAIN AND PAIN ASSOCIATED WITH NEUROPATHY | TRINITY LABORTORIES, INC. (US) | 2009-02-12 | — | — | WO | disclosed |
| WO-2008131256-A1 | IMPROVED TREATMENTS FOR PREMATURE EJACULATION IN HUMANS | TRINITY LABORATORIES INC. (US) | 2008-10-30 | — | — | WO | disclosed |
| US-20080058362-A1 | Novel pharmaceutical compositions for treating chronic pain and pain associated with neuropathy | JEFFERSON BANK | 2008-03-06 | — | — | US | disclosed |
| US-20080020996-A1 | Esters of capsaicin for treating pain | JEFFERSON BANK | 2008-01-24 | — | — | US | disclosed |
| US-20080020996-A1 | Esters of capsaicin for treating pain | JEFFERSON BANK | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218180-A1 | Esters of Capsaicin for Treating Pain | FAAH, APEH, FFAR1 | TRPV1 19/4885CYP1A2 152/4885CYP3A4 477/4885 |
| US-11773055-B2 | Chemical derivatives and methods for synthesizing and compounding chemical derivatives related to capsaicin palmitate and capsaicin prodrugs | HCAR2, HCAR3, TRPV1 | TRPV1 3/4885CYP1A2 910/4885CYP3A4 588/4885 |
| US-12458611-B1 | Stable forms of capsaicin palmitate for the treatment of pain | TRPV1, FFAR3, TRPV3 | TRPV1 1/4885CYP1A2 1572/4885CYP3A4 1783/4885 |
| US-12358868-B2 | Chemical derivatives and methods for synthesizing and compounding chemical derivatives related to capsaicin palmitate and capsaicin prodrugs | HCAR2, HCAR3, TRPV1 | TRPV1 3/4885CYP1A2 910/4885CYP3A4 588/4885 |
| US-20140134261-A1 | Pharmaceutical Compositions Comprising Capsaicin Esters for Treating Pain and Cold Sores | TRPV1, ALOX12, OPRK1 | TRPV1 1/4885CYP1A2 1782/4885CYP3A4 2701/4885 |
| US-20220168259-A1 | CHEMICAL DERIVATIVES AND METHODS FOR SYNTHESIZING AND COMPOUNDING CHEMICAL DERIVATIVES RELATED TO CAPSAICIN PALMITATE AND CAPSAICIN PRODRUGS | HCAR2, HCAR3, TRPV1 | TRPV1 3/4885CYP1A2 910/4885CYP3A4 588/4885 |
| US-20100120912-A1 | Esters of capsaicinoids as dietary supplements | SI, LIPA, PNLIP | TRPV1 12/4885CYP1A2 215/4885CYP3A4 240/4885 |
| US-20230406816-A1 | CHEMICAL DERIVATIVES AND METHODS FOR SYNTHESIZING AND COMPOUNDING CHEMICAL DERIVATIVES RELATED TO CAPSAICIN PALMITATE AND CAPSAICIN PRODRUGS | HCAR2, HCAR3, TRPV1 | TRPV1 3/4885CYP1A2 910/4885CYP3A4 588/4885 |
| US-20260115155-A1 | STABLE FORMS OF CAPSAICIN PALMITATE FOR THE TREATMENT OF PAIN | TRPV1, SPTLC3, FFAR3 | TRPV1 1/4885CYP1A2 1412/4885CYP3A4 1406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.