Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.54 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.47 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.47 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20577767 | 0.84 | RXFP1 (0.53) | LMNAPTGS1GAAKCNK3P2RX1 | |
| SCHEMBL20577803 | 0.82 | PTGS1 (0.64) | LMNAPTGS1GAAKCNK3P2RX1 | |
| SCHEMBL19233247 | 0.82 | PTGS1 (0.52) | LMNAPTGS1GAAKCNK3P2RX1 | |
| SCHEMBL19233515 | 0.80 | PTGS1 (0.68) | LMNAPTGS1GAAKCNK3P2RX1 | |
| SCHEMBL30739971 | 0.78 | HDAC1 (0.46) | LMNAPTGS1GAAKCNK3P2RX1 | |
| SCHEMBL28317667 | 0.77 | MEN1 (0.50) | KCNK3ALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL28316859 | 0.77 | MEN1 (0.47) | LMNAKCNK3ALDH1A1KMT2AMEN1 | |
| SCHEMBL28668959 | 0.76 | LMNA (0.83) | LMNAPTGS1GAAKCNK3P2RX1 | |
| SCHEMBL30739787 | 0.76 | PTGS1 (0.65) | LMNAPTGS1GAAKCNK3P2RX1 | |
| SCHEMBL28316754 | 0.76 | HDAC1 (0.46) | GAAP2RX1ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071543-B | Pyridine derivatives inhibiting RAF kinase and vascular endothelial growth factor receptor, process for their preparation, pharmaceutical compositions containing them and their use | 三进制药株式会社 | 2021-07-16 | — | — | CN | disclosed |