SCHEMBL2893149

SCHEMBL2893149

O=C1NC(=O)C(Cl)C(=O)N1

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.39
KDM4E B2RXH2 1/20 0.35
OGT O15294 1/20 0.35
USP2 O75604 1/20 0.35
MAPT P10636 1/20 0.35
RECQL P46063 1/20 0.35
BLM P54132 1/20 0.35
HSD17B10 Q99714 2/20 0.34
LMNA P02545 1/20 0.32
RGS12 O14924 1/20 0.30
BACE1 P56817 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31114 0.69
SCHEMBL10988745 0.67 TSHR (0.39) TSHRKDM4EOGTUSP2MAPT
SCHEMBL133284 0.67 HSD17B10 (0.39) TSHRKDM4EOGTUSP2MAPT
SCHEMBL9211477 0.67 TSHR (0.39) TSHRKDM4EOGTUSP2MAPT
SCHEMBL131371 0.67 TSHR (0.39) TSHRKDM4EOGTUSP2MAPT
Water SCHEMBL11883570 0.65 HSD17B10 (0.38) TSHRKDM4EOGTUSP2MAPT
SCHEMBL8647881 0.65 TSHR (0.38) TSHRKDM4EOGTUSP2MAPT
SCHEMBL17294184 0.65 TSHR (0.50) TSHRKDM4EOGTUSP2MAPT
SCHEMBL5842299 0.65
SCHEMBL2873513 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104127469-A New application of olive leaf crude extract and tumor therapeutic drug combined kit thereof SHANGHAI YUXIAN MEDICAL TECHNOLOGY CO LTD 2014-11-05 CN claimed
CN-1923173-A Anti-cancer drugs slow release agent comprising anticancer antibiotics and booster thereof JINAN KANGQUAN PHARMACEUTICAL (CN) 2007-03-07 CN claimed
CN-1857723-A Slow released anticancer medicine preparation with both amrubicin and its synergist KANGQUAN MEDICINE SCI TECH CO (CN) 2006-11-08 CN claimed
CN-1634584-A Anti-cancer medicine composition containing antimetabolite SHANDONG LANJIN BIOENGINEERING (CN) 2005-07-06 CN claimed
CN-104127469-A New application of olive leaf crude extract and tumor therapeutic drug combined kit thereof SHANGHAI YUXIAN MEDICAL TECHNOLOGY CO LTD 2014-11-05 CN disclosed
CN-101244272-B Anti-solid tumors pharmaceutical combination containing topological enzyme inhibitor SHANDONG LANJIN BIOENGINEERING CO LTD 2010-07-14 CN disclosed
CN-1927175-B Compound recipe anticancer slow release injection comprising tetrazole violet JINAN SHUAIHUA PHARMACEUTICAL TECHNOLOGY CO LTD 2010-05-19 CN disclosed
CN-1923173-B Anti-cancer drugs slow release agent comprising anticancer antibiotics and synergist thereof JINAN KANGQUAN PHARMACEUTICAL CO LTD 2010-05-19 CN disclosed
US-7666977-B2 Poly(carbonate-co-urea) copolymers and melt transesterification method of preparing these copolymers SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2010-02-23 US disclosed
US-7557175-B2 Poly(carbonate-co-urea) copolymers and melt transesterification method of preparing these copolymers SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2009-07-07 US disclosed
CN-100500212-C Anti entity tumour medicinal composition SHANDONG LANJIN BIOLOG ENGINEE (CN) 2009-06-17 CN disclosed
CN-100500218-C Anti tumour medicinal composition SHANDONG LANJIN BIOLOG ENGINEE (CN) 2009-06-17 CN disclosed
CN-1686554-A Anti entity tumour medicinal composition containing platinum compound SHANDONG LANJIN BIOLOG ENGINEE (CN) 2005-10-26 CN disclosed
CN-1686552-A Anti-solid tumor pharmaceutical composition containing topoisomerase inhibitor SHANDONG LANJIN BIOLOG ENGINEE (CN) 2005-10-26 CN disclosed
CN-1686555-A Anti entity tumour medicinal composition containing tetrazine kind compound SHANDONG LANJIN BIOLOG ENGINEE (CN) 2005-10-26 CN disclosed
CN-1686553-A Anti entity tumour medicinal composition SHANDONG LANJIN BIOLOG ENGINEE (CN) 2005-10-26 CN disclosed
CN-1679950-A Anticarcinogenic internal implant agent LANJIN BIOLOG ENGINEERING CO L (CN) 2005-10-12 CN disclosed
CN-1679944-A Anticarcinogen composition LANJIN BIOLOG ENGINEERING CO L (CN) 2005-10-12 CN disclosed
CN-1634584-A Anti-cancer medicine composition containing antimetabolite SHANDONG LANJIN BIOENGINEERING (CN) 2005-07-06 CN disclosed
CN-1634586-A Anti-cancer medicine composition SHANDONG LANJIN BIOENGINEERING (CN) 2005-07-06 CN disclosed