Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | OGT | O15294 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RGS12 | O14924 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1362681 | 0.69 | — | — | |
| SCHEMBL133284 | 0.67 | HSD17B10 (0.39) | TSHRKDM4EOGTUSP2MAPT | |
| SCHEMBL2893149 | 0.67 | TSHR (0.39) | TSHRKDM4EOGTUSP2MAPT | |
| SCHEMBL10988745 | 0.67 | TSHR (0.39) | TSHRKDM4EOGTUSP2MAPT | |
| Water SCHEMBL11883570 | 0.65 | HSD17B10 (0.38) | TSHRKDM4EOGTUSP2MAPT | |
| SCHEMBL8647881 | 0.65 | TSHR (0.38) | TSHRKDM4EOGTUSP2MAPT | |
| SCHEMBL17294184 | 0.65 | TSHR (0.50) | TSHRKDM4EOGTUSP2MAPT | |
| SCHEMBL15013628 | 0.65 | — | — | |
| SCHEMBL2873513 | 0.64 | — | — | |
| SCHEMBL20387031 | 0.63 | TSHR (0.36) | TSHRKDM4EOGTUSP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5414085-A | Barbiturate derivatives and protein and polypeptide barbiturate derivative conjugates and labels | BIOSITE DIAGNOSTICS, INC. (US) | 1995-05-09 | — | — | US | disclosed |
| EP-0635013-A4 | NOVEL BARBITURATE DERIVATIVES AND PROTEIN AND POLYPEPTIDE BARBITURATE DERIVATIVE CONJUGATES AND LABELS. | BIOSITE DIAGNOSTICS INC (US) | 1995-03-22 | — | — | EP | disclosed |
| EP-0635013-A1 | NOVEL BARBITURATE DERIVATIVES AND PROTEIN AND POLYPEPTIDE BARBITURATE DERIVATIVE CONJUGATES AND LABELS | BIOSITE DIAGNOSTICS INC. (US) | 1995-01-25 | — | — | EP | disclosed |
| WO-1993020064-A1 | NOVEL BARBITURATE DERIVATIVES AND PROTEIN AND POLYPEPTIDE BARBITURATE DERIVATIVE CONJUGATES AND LABELS | BIOSITE DIAGNOSTICS INCORPORATED (US) | 1993-10-14 | — | — | WO | disclosed |